BIOMAT Database Logo BIOMAT Database Logo

Familial incidence of C3 nephritic factor. 1991

M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
Immunology Unit, Hospital La Paz, Madrid, Spain.

C3 nephritic factor (NEF) has been found in 3 siblings presenting different (or none) degrees of renal disease. Other relatives, including their dead father, suffered from a renal illness. In 2 of the siblings, NEF activity was restricted to IgG1 and IgG3 subclasses. Familial NEF incidence and a shared C3 allotype and a common HLA haplotype including BfS alleles for the 3 NEF-positive siblings suggest that at least in our cases genetical factors may be involved in NEF generation.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D003176 Complement C3 A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase. C3 Complement,C3 Precursor,Complement 3,Complement C3 Precursor,Complement Component 3,Precursor-Complement 3,Pro-C3,Pro-Complement 3,C3 Precursor, Complement,C3, Complement,Complement, C3,Component 3, Complement,Precursor Complement 3,Precursor, C3,Precursor, Complement C3,Pro C3,Pro Complement 3
D003178 Complement C3 Nephritic Factor An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis. C3 NeF,C3 NeF IgG Autoantibodies,C3 NeF IgG Autoantibody,C3NeF IgG Autoantibodies,C3NeF IgG Autoantibody,C 3 Nephritic Factor,C3 Nephritic Factor,Complement 3 Nephritic Factor,Autoantibody, C3NeF IgG,IgG Autoantibody, C3NeF
D003181 Complement C4 A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B. C4 Complement,C4 Complement Component,Complement 4,Complement C4, Precursor,Complement Component 4,Pro-C4,Pro-complement 4,C4, Complement,Complement Component, C4,Complement, C4,Component 4, Complement,Component, C4 Complement,Pro C4,Pro complement 4
D005260 Female Females
D005921 Glomerulonephritis Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY. Bright Disease,Kidney Scarring,Glomerulonephritides,Scarring, Kidney
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human

Related Publications

M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
Familial incidence of C3 nephritic factor, partial lipodystrophy and membranoproliferative glomerulonephritis.
April 1990, The Quarterly journal of medicine,
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
Transfer of C3 nephritic factor from mother to fetus. Is C3 nephritic factor IgG?
July 1977, The New England journal of medicine,
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
C3 nephritic factor stabilization of the classic C3 convertase: a role for C2 in C3 nephritic factor activity.
July 1979, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
C3 nephritic factor and mesangiocapillary glomerulonephritis.
February 1997, Pediatric nephrology (Berlin, Germany),
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
C3 nephritic factor associated with C3 glomerulopathy in children.
January 2014, Pediatric nephrology (Berlin, Germany),
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis (MPGN).
February 1994, Clinical and experimental immunology,
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
IgG subclass studies of C3 nephritic factor.
September 1978, Clinical immunology and immunopathology,
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
Lupus, C3 nephritic factor and partial lipodystrophy.
April 1995, QJM : monthly journal of the Association of Physicians,
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
A healthy female with C3 hypocomplementemia and C3 Nephritic Factor.
August 2016, Clinical immunology (Orlando, Fla.),
M López-Trascasa, and J M Martín-Villa, and J L Vicario, and M A Marín, and J Martínez-Ara, and M C García-Messeguer, and A Arnáiz-Villena, and G Fontán
Detection of C3 Nephritic Factor by Hemolytic Assay.
January 2021, Methods in molecular biology (Clifton, N.J.),
Copied contents to your clipboard!