-transparent.png){kind=logo}
To investigate the biological activities of the hopane group of pentacyclic triterpenoids, we isolated one hopanoid, bacteriohopane-32-ol from Rhodopseudomonas palustris and tested its cytotoxicity against mouse leukemia cells in vitro. The IC50 of the hopanoid for L1210 and P388 was 22 and 19 microM respectively. This activity was slightly reduced by co-incubation with cholesterol. As the mechanism of cytotoxic action, disturbances of membrane function and metabolism are discussed.
Related Publications
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
November 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
May 1992,
Chemical & pharmaceutical bulletin,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
March 1995,
Biological & pharmaceutical bulletin,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
November 2003,
Phytomedicine : international journal of phytotherapy and phytopharmacology,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
March 1984,
Cancer treatment reports,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
April 1966,
Experimental cell research,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
March 1983,
Journal of the National Cancer Institute,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
March 1991,
Research communications in chemical pathology and pharmacology,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
September 1990,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
A Nagumo, and
K Takanashi, and
H Hojo, and
Y Suzuki
April 1995,
Biological & pharmaceutical bulletin,
