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The metabolism of isotopically-labelled cholecalciferol and the response to small doses of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) was studied in a group of women with osteoporosis presenting with crush vertebral fracture. No abnormality of vitamin D metabolism was detected. The administration of 1 microgram 1,25-(OH)2D3 for between 8 and 20 days was associated with an increased intestinal absorption and urinary excretion of calcium but caused no improvement in calcium balance. There was a small but significant rise in serum calcium and phosphorus and significant reduction in immunoassayable parathyroid hormone levels during treatment. It is concluded that 1,25-(OH)2D3 is unlikely to be of value in the management of osteoporosis.
M Davies, and
E B Mawer, and
P H Adams
March 1973,
The Journal of clinical investigation,
M Davies, and
E B Mawer, and
P H Adams
October 1977,
The Journal of nutrition,
M Davies, and
E B Mawer, and
P H Adams
April 1977,
The Biochemical journal,
M Davies, and
E B Mawer, and
P H Adams
August 1971,
Nature: New biology,
M Davies, and
E B Mawer, and
P H Adams
January 1974,
Recent progress in hormone research,
M Davies, and
E B Mawer, and
P H Adams
July 2004,
Indian journal of clinical biochemistry : IJCB,
M Davies, and
E B Mawer, and
P H Adams
June 1985,
Nutrition reviews,
M Davies, and
E B Mawer, and
P H Adams
May 1984,
The American journal of physiology,
M Davies, and
E B Mawer, and
P H Adams
September 1980,
Lancet (London, England),
M Davies, and
E B Mawer, and
P H Adams
January 1972,
Nutrition reviews,
