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In Dupuytren's contracture there is an increase in the ratio of type III to type I collagen. The objective of this study was to determine if fibroblasts from patients with Dupuytren's contracture have an intrinsic aberration in collagen production or whether local factors govern the collagen changes in Dupuytren's contracture. Using a new collagen micro-method, we found that fibroblasts cultured from palmar fascia affected by Dupuytren's contracture produced similar collagen to fibroblasts derived from the palmar fascia of age- and sex-matched patients with carpal tunnel syndrome. Furthermore, the collagen changes of Dupuytren's contracture could be reproduced in all cell lines by increasing fibroblast density. At high fibroblast density, type I collagen production was inhibited: a finding that could account for the increased types III/I collagen ratio in Dupuytren's contracture. These results suggest that a genetic defect in collagen production is unlikely and that the important phenomenon is an increase in fibroblast density.
G A Murrell, and
M J Francis, and
L Bromley
January 1978,
Voprosy meditsinskoi khimii,
G A Murrell, and
M J Francis, and
L Bromley
January 1981,
Chirurgia narzadow ruchu i ortopedia polska,
G A Murrell, and
M J Francis, and
L Bromley
January 1978,
Chirurgia narzadow ruchu i ortopedia polska,
G A Murrell, and
M J Francis, and
L Bromley
July 1971,
Annals of the rheumatic diseases,
G A Murrell, and
M J Francis, and
L Bromley
January 1984,
The Journal of hand surgery,
G A Murrell, and
M J Francis, and
L Bromley
July 1987,
Morphologiai es igazsagugyi orvosi szemle,
G A Murrell, and
M J Francis, and
L Bromley
February 1986,
Journal of hand surgery (Edinburgh, Scotland),
G A Murrell, and
M J Francis, and
L Bromley
January 1954,
American journal of surgery,
G A Murrell, and
M J Francis, and
L Bromley
August 1968,
Beitrage zur Orthopadie und Traumatologie,
G A Murrell, and
M J Francis, and
L Bromley
February 1946,
Canadian Medical Association journal,
