Neonatal thymic contrasuppressor activity on graft versus host reactions towards self histocompatibility antigens. Parental effects. 1991

S Torello, and A Déroche, and I Nepomnaschy, and V Buggiano, and A Goldman, and I Piazzon
Academia Nacional de Medicina, Instituto de Investigaciones Hematológicas, Buenos Aires, Argentina.

The ability of fetal and neonatal F1 thymocytes to regulate parental graft versus host (GvH) reactions against self histocompatibility antigens was investigated. The results obtained showed that: (1) fetal F1 thymocytes were able to suppress both maternal and paternal GvH reactivity; (2) at birth, thymocytes were still able to suppress maternal GvH reactivity while no suppression of paternal reactions was detected; the ability to suppress maternal GvH reactions could be detected until day 3; (3) the loss of suppressor activity correlated with the ability of thymocytes to contrasuppress parental GvH reactions. Thus, 24-h F1 thymocytes showed contrasuppressor activity on paternal GvH reactivity and 4-day thymocytes on maternal reactivity. Thymic cells with contrasuppressor activity were shown to be Lyt-1+, CD4+, CD8- and adherent to Vicia villosa. These results suggest the existence of parental effects influencing the duration of thymic suppression and the subsequent appearance of contrasuppressor activity on GvH reactions against self histocompatibility antigens, according to the maternal or paternal origin of self antigens towards which the reaction is directed.

UI MeSH Term Description Entries
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011975 Receptors, Mitogen Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes. Lectin Receptors,Mitogen Receptors,Receptors, Lectin,Mitogen Receptor,Receptor, Mitogen
D003433 Crosses, Genetic Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species. Cross, Genetic,Genetic Cross,Genetic Crosses
D005260 Female Females
D006087 Graft vs Host Reaction An immunological attack mounted by a graft against the host because of HISTOINCOMPATIBILITY when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE. HLA Sensitization,Human Leukocyte Antigen Sensitization,Sensitization, HLA
D006649 Histocompatibility Antigens A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection. Transplantation Antigens,Antigens, Transplantation,Histocompatibility Antigen,LD Antigens,SD Antigens,Antigen, Histocompatibility,Antigens, Histocompatibility,Antigens, LD,Antigens, SD
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals

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