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Enrichment and terminal differentiation of striated muscle progenitors in vitro. 2009
Ulrich M Becher, and
Martin Breitbach, and
Philipp Sasse, and
Stephan Garbe, and
Peter F M van der Ven, and
Dieter O Fürst, and
Bernd K Fleischmann
Institute of Physiology I, Life and Brain Center, University of Bonn, Bonn, Germany.
Enrichment and terminal differentiation of mammalian striated muscle cells is severely hampered by fibroblast overgrowth, de-differentiation and/or lack of functional differentiation. Herein we report a new, reproducible and simple method to enrich and terminally differentiate muscle stem cells and progenitors from mice and humans. We show that a single gamma irradiation of muscle cells induces their massive differentiation into structurally and functionally intact myotubes and cardiomyocytes and that these cells can be kept in culture for many weeks. Similar results are also obtained when treating skeletal muscle-derived stem cells and progenitors with Mitomycin C.
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