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The stabilities and translation of Ehrlich ascites tumor cell poly(A)-containing mRNA and mengovirus RNA in fractionated cell-free protein synthesizing systems from uninfected and mengovirus-infected Ehrlich ascites tumor cells were studied. During incubation of the systems about 20% of the input RNA is reduced in size and associated with ribosomes engaged in polypeptide synthesis; the remainder is rapidly degraded by RNases. At the end of active translation, both mRNA and nascent proteins are bound to polysomes which are of the same size as those formed during active protein synthesis. The kinetics of protein synthesis closely follow those of RNA hydrolysis. The stabilities of mengovirus RNA and poly(A)-containing mRNA from Ehrlich ascites tumor cells are the same in both systems.
P B Hackett, and
E Egberts, and
P Traub
December 1977,
European journal of biochemistry,
P B Hackett, and
E Egberts, and
P Traub
January 1983,
Methods in enzymology,
P B Hackett, and
E Egberts, and
P Traub
April 1976,
Journal of virology,
P B Hackett, and
E Egberts, and
P Traub
February 1978,
Molecular biology reports,
P B Hackett, and
E Egberts, and
P Traub
April 1975,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
P B Hackett, and
E Egberts, and
P Traub
January 1977,
Virologie,
P B Hackett, and
E Egberts, and
P Traub
December 1982,
European journal of biochemistry,
P B Hackett, and
E Egberts, and
P Traub
October 1978,
Molecular biology reports,
P B Hackett, and
E Egberts, and
P Traub
April 1974,
Biochemical and biophysical research communications,
P B Hackett, and
E Egberts, and
P Traub
February 1987,
Lipids,
