An anthropomorphic phantom study of computer-aided detection performance for polyp detection on CT colonography: a comparison of commercially and academically available systems. 2009

Min Woo Lee, and Se Hyung Kim, and Hee Sun Park, and June-Goo Lee, and Seung Moon Joo, and Sangbu An, and Byung Ihn Choi
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

OBJECTIVE The objective of our study was to compare the diagnostic performances of two commercial computer-aided detection (CAD) systems and a CAD system developed in our laboratory, which we refer to as an "academic CAD system," for polyp detection on CT colonography (CTC) and to assess the detection characteristics of the CAD systems. METHODS One hundred three polyps (48 polyps < 6 mm and 55 polyps > or = 6 mm; 45 sessile, 33 flat, and 25 pedunculated polyps) were created. Each CTC data set was analyzed using two commercial CAD systems (Computer Assisted Reader [CAR] and Polyp Enhanced View [PEV]) and one Hessian matrix-based academic CAD system. Per-polyp sensitivities according to polyp size and shape were compared among the three CAD systems. The average number and causes of false-positives (FPs) were analyzed and compared. RESULTS Per-polyp sensitivity for all polyps was significantly better for the academic CAD system (83.5%) than for both commercial CAD systems (64.1%) (p < 0.01). However, the difference in per-polyp sensitivity for polyps > or = 6 mm was not significant (p > 0.017). According to morphology, per-polyp sensitivities as determined with the CAR, PEV, and academic CAD systems for flat, sessile, and pedunculated polyps were 51.5%, 57.6%, and 81.8%; 60.0%, 62.2%, and 84.4%; 88.0%, 76.0%, and 84.0%, respectively. The average number of FPs was not significantly different (p > 0.05); however, the distribution of the causes of FPs for the three systems was significantly different (p < 0.001). CONCLUSIONS For polyps > or = 6 mm, the three CAD systems showed comparable per-polyp sensitivities. Although the number of FPs was not significantly different, the distribution of the causes of FPs for each of the CAD systems was significantly different.

UI MeSH Term Description Entries
D003111 Colonic Polyps Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base. Colonic Polyp,Polyp, Colonic,Polyps, Colonic
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D003936 Diagnosis, Computer-Assisted Application of computer programs designed to assist the physician in solving a diagnostic problem. Computer-Assisted Diagnosis,Computer Assisted Diagnosis,Computer-Assisted Diagnoses,Diagnoses, Computer-Assisted,Diagnosis, Computer Assisted
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D012984 Software Sequential operating programs and data which instruct the functioning of a digital computer. Computer Programs,Computer Software,Open Source Software,Software Engineering,Software Tools,Computer Applications Software,Computer Programs and Programming,Computer Software Applications,Application, Computer Software,Applications Software, Computer,Applications Softwares, Computer,Applications, Computer Software,Computer Applications Softwares,Computer Program,Computer Software Application,Engineering, Software,Open Source Softwares,Program, Computer,Programs, Computer,Software Application, Computer,Software Applications, Computer,Software Tool,Software, Computer,Software, Computer Applications,Software, Open Source,Softwares, Computer Applications,Softwares, Open Source,Source Software, Open,Source Softwares, Open,Tool, Software,Tools, Software
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D017076 Computer-Aided Design The use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics. CAD-CAM,Computer-Aided Manufacturing,Computer-Assisted Design,Computer-Assisted Manufacturing,Computer Aided Design,Computer Aided Manufacturing,Computer Assisted Design,Computer Assisted Manufacturing,Computer-Aided Designs,Computer-Assisted Designs,Design, Computer-Aided,Design, Computer-Assisted,Designs, Computer-Aided,Designs, Computer-Assisted,Manufacturing, Computer-Aided,Manufacturing, Computer-Assisted
D019047 Phantoms, Imaging Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990) Phantoms, Radiographic,Phantoms, Radiologic,Radiographic Phantoms,Radiologic Phantoms,Phantom, Radiographic,Phantom, Radiologic,Radiographic Phantom,Radiologic Phantom,Imaging Phantom,Imaging Phantoms,Phantom, Imaging
D023881 Colonography, Computed Tomographic A non-invasive imaging method that uses computed tomographic data combined with specialized imaging software to examine the colon. Colonoscopy, Virtual,Computed Tomographic Colonography,Virtual Colonoscopy,CT Colonography,Colonography, CT

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