Surface graft polymerization of poly(ethylene glycol) methacrylate onto polyurethane via thiol-ene reaction: preparation and characterizations. 2009

In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
Department of Molecular Science and Technology, Ajou University, 5 Wonchon, Yeoungtong, Suwon 443-749, South Korea.

A new surface modification that facilitates the grafting of poly(ethylene glycol) methacrylate (PEGMA) on a polyurethane (PU) surface was developed using a thiol-ene reaction. The thiolated PU surface for the grafting of PEGMA was created by fabricating allylated PU through an allophanate reaction, which was then modified with tetra-thiols to enhance the functionality of the PU surface. The amount of thiol groups increased with increasing irradiation time, and its concentration was almost equilibrated after 30 min irradiation. ESCA spectra revealed new two peaks on the thiolated PU surface at 163 and 228 eV, which was assigned to sulfur, and a significant increase in the oxygen content of the poly(PEGMA)-grafted PU was shown as compared with the other groups. Also, the irradiation time-dependent increase in the surface wettability of poly(PEGMA)-grafted PU was confirmed by contact angle measurement. These surface characteristics support that poly(PEGMA)-grafted PU was successfully prepared using a thiol-ene reaction. For in vitro protein adsorption and cell proliferation tests, the poly(PEGMA)-grafted PU surface showed repellent properties against both fibrinogen and smooth muscle cells, compared to other groups. This surface graft polymerization of PEGMA on a PU surface via a thiol-ene reaction can be used as a promising surface modification for improving blood compatibility of PU-based blood-contacting devices.

UI MeSH Term Description Entries
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D011092 Polyethylene Glycols Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS. Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D011140 Polyurethanes A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams. Polyisocyanates,Ostamer,Pellethane,Spandex,Ostamers,Pellethanes,Polyisocyanate,Polyurethane,Spandices
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005340 Fibrinogen Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products. Coagulation Factor I,Factor I,Blood Coagulation Factor I,gamma-Fibrinogen,Factor I, Coagulation,gamma Fibrinogen
D000327 Adsorption The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily. Adsorptions
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001011 Aorta The main trunk of the systemic arteries. Aortas
D013438 Sulfhydryl Compounds Compounds containing the -SH radical. Mercaptan,Mercapto Compounds,Sulfhydryl Compound,Thiol,Thiols,Mercaptans,Compound, Sulfhydryl,Compounds, Mercapto,Compounds, Sulfhydryl
D013499 Surface Properties Characteristics or attributes of the outer boundaries of objects, including molecules. Properties, Surface,Property, Surface,Surface Property

Related Publications

In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
February 2019, Journal of nanoscience and nanotechnology,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
December 2009, Journal of biomedical materials research. Part A,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
December 2010, Journal of biomedical materials research. Part A,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
June 2003, Journal of colloid and interface science,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
June 2013, Macromolecules,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
December 1993, Journal of biomedical materials research,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
April 2005, Journal of colloid and interface science,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
June 2003, Journal of colloid and interface science,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
November 2020, RSC advances,
In Kwon Jung, and Jin Woo Bae, and Won Sup Choi, and Jong Hoon Choi, and Ki Dong Park
May 2001, Journal of cataract and refractive surgery,
Copied contents to your clipboard!