BIOMAT Database Logo BIOMAT Database Logo

Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma. 1991

M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
Department of Internal Medicine, Misasa Medical Branch, Okayama University, Medical School, Tottori, Japan.

Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008925 Mites Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants. Acarus,Mite
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003888 Desensitization, Immunologic Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity. Allergen Immunotherapy,Allergy Shots,Hyposensitization Therapy,Immunotherapy, Allergen,Venom Immunotherapy,Immunologic Desensitization,Therapy, Hyposensitization,Allergen Immunotherapies,Allergy Shot,Desensitizations, Immunologic,Hyposensitization Therapies,Immunologic Desensitizations,Immunotherapy, Venom,Shot, Allergy,Venom Immunotherapies
D004391 Dust Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed) House Dust,Housedust,Dust, House
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked

Related Publications

M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
IgG4 antibodies in patients with house-dust-mite-sensitive bronchial asthma: relationship with antigen-specific immunotherapy.
January 1983, International archives of allergy and applied immunology,
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
House dust mite-specific IgE, IgG1, and IgG4 antibodies in patients with perennial rhinitis.
January 1987, The Annals of otology, rhinology, and laryngology,
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
Analysis of house dust mite-specific IgE, IgG4, and IgG antibodies during immunotherapy in asthmatic children.
July 1991, Annals of allergy,
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
[Specific IgG and IgE antibodies in house dust mite asthmatic patients and control probands].
February 1990, Pneumologie (Stuttgart, Germany),
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
[Changes in antigen-specific IgG, IgG4, and IgE antibodies in patients receiving immunotherapy with house-dust extract].
July 1993, Arerugi = [Allergy],
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
Changes of house dust mite-specific IgE, IgG and IgG subclass antibodies during immunotherapy in patients with perennial rhinitis.
January 1987, International archives of allergy and applied immunology,
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
IgE, IgG, and IgG4 antibody titers to fractionated house dust mite antigens in nasal allergy patients.
April 1992, Acta medica Okayama,
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
IgE antibodies to house dust mite in patients with scabies.
September 1980, The British journal of dermatology,
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
Specific IgE and IgG4 Profiles of House Dust Mite Components in Allergen-Specific Immunotherapy.
January 2021, Frontiers in immunology,
M Okazaki, and H Kitani, and T Mifune, and F Mitsunobu, and N Asaumi, and Y Tanizaki, and H Harada, and K Takahashi, and I Kimura
[House dust mite allergy and allergic bronchial asthma (II). Clinical aspects of house dust mite allergy and specific therapy in sensitization against house dust mites].
May 1981, ZFA. Zeitschrift fur Allgemeinmedizin,
Copied contents to your clipboard!