-transparent.png){kind=logo}
Circular dichroism (CD) and UV/Visible absorption (UV/Vis) spectroscopy techniques were used to investigate the interaction between heparin and chloroquine, an antimalarial drug that has shown potential as an anti-prion agent. CD spectra of rac-chloroquine upon addition of heparin provide evidence of glycosaminoglycan (GAG) binding, support recent findings suggesting that interactions between heparin and antimalarial drugs are largely due to electrostatic interactions, and represent the first reported GAG-induced CD signal of a bicyclic, aromatic compound. The association constant ( approximately 10(3)M(-1)) between chloroquine and heparin was calculated from a UV titration curve and provided additional insight into the nature of the association between these two compounds.
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
December 1982,
Proceedings of the National Academy of Sciences of the United States of America,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
October 1982,
Biochemical and biophysical research communications,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
September 1984,
Biochemical and biophysical research communications,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
September 2003,
Organic letters,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
July 1976,
Biopolymers,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
March 2022,
Chirality,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
July 1983,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
April 2010,
Biochemical and biophysical research communications,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
January 2011,
Analytical and bioanalytical chemistry,
F E Stanley, and
A M Warner, and
S M Gutierrez, and
A M Stalcup
June 2013,
General physiology and biophysics,
