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The cytotoxic effects of ferric nitrilotriacetate (Fe-NTA) have been considered to be caused by free radicals produced by the drug. The present study was carried out to determine whether or not cytotoxic effects of Fe-NTA on cell growth and lipoperoxide formation of Chinese hamster cells were reduced by antioxidants. Using a spin trapping technique, we found that hydroxyl radical formation in the cells increased in the presence of Fe-NTA. Antioxidants, with the exception of superoxide dismutase, slightly inhibited production of the hydroxyl radical. Mannitol significantly reduced lipoperoxide formation, but other antioxidants did not. However, the growth inhibitory effects of Fe-NTA were not attenuated by these antioxidants. These results indicated that the cytotoxic effects of Fe-NTA may be mostly due to unknown factors other than oxygen free radicals.
Y Takehara, and
T Yoshioka, and
M Namba
February 1990,
Carcinogenesis,
Y Takehara, and
T Yoshioka, and
M Namba
February 1988,
Mutation research,
Y Takehara, and
T Yoshioka, and
M Namba
June 1983,
American journal of clinical oncology,
Y Takehara, and
T Yoshioka, and
M Namba
February 1985,
Shigaku = Odontology; journal of Nihon Dental College,
Y Takehara, and
T Yoshioka, and
M Namba
June 1990,
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Y Takehara, and
T Yoshioka, and
M Namba
November 1985,
Mutation research,
Y Takehara, and
T Yoshioka, and
M Namba
July 1981,
Mutation research,
Y Takehara, and
T Yoshioka, and
M Namba
July 1980,
Mutation research,
Y Takehara, and
T Yoshioka, and
M Namba
December 1984,
National Cancer Institute monograph,
Y Takehara, and
T Yoshioka, and
M Namba
April 1989,
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