[Preparation of the vaccine with inactivated Feline Panleukopenia Virus isolated from tiger and the preliminary application]. 2009

Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China. yuyali_1984@163.com

OBJECTIVE To prepare a vaccine with inactivated Feline Panleukopenia Virus (FPV) isolated from Siberian tigers and to evaluate its immunological effect. METHODS FPV-HLJ, an FPV strain previously isolated from Siberian tiger in our lab was used to inoculate cat kidney cell line F81 with dose 1/10(v/v) using the synchronizing inoculation method. Inoculated F81 cell line was cultured at 37 degrees C and collected when cytopathic effect was up to 75%. Viral suspension was inactivated by using formaldehyde for 24 h and inactive vaccine preapred by adding aluminium hydroxide gel as adjuvant to the suspension. The inactive vaccine was applied to 2-month-old kitten tigers of hypodermically after protection effect was proved in 2-month-old nonimmunized cats by using the same vaccination procedure. RESULTS Antibody level in vaccinated cats revealed an increasing trend that the valence of antibody reached 1:1024-2048 after three times of vaccination. All vaccinated cats survived challenges of virulent FPV virus. The valence of antibody reached 1:1024 in most vaccinated tigers 15 days after the third vaccination. CONCLUSIONS The results indicated that the inactivated vaccine can produce immunoprotection for tigers.

UI MeSH Term Description Entries
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005254 Feline Panleukopenia A highly contagious DNA virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. It is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. It is caused by FELINE PANLEUKOPENIA VIRUS or the closely related MINK ENTERITIS VIRUS or CANINE PARVOVIRUS. Agranulocytosis, Feline,Ataxia, Feline,Cat Plague,Distemper, Feline,Feline Ataxia,Feline Infectious Enteritis,Panleukopenia, Feline,Show Fever,Agranulocytoses, Feline,Ataxias, Feline,Cat Plagues,Distempers, Feline,Enteritides, Feline Infectious,Enteritis, Feline Infectious,Feline Agranulocytoses,Feline Agranulocytosis,Feline Ataxias,Feline Distemper,Feline Distempers,Feline Infectious Enteritides,Feline Panleukopenias,Fever, Show,Fevers, Show,Infectious Enteritides, Feline,Infectious Enteritis, Feline,Panleukopenias, Feline,Plague, Cat,Plagues, Cat,Show Fevers
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012800 Siberia A region, north-central Asia, largely in Russia. It extends from the Ural Mountains to the Pacific Ocean and from the Arctic Ocean to central Kazakhstan and the borders of China and Mongolia. Russian S.F.S.R., Asian,Russian Federation (Asia)
D014611 Vaccination Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis. Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations
D014765 Viral Vaccines Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease. Viral Vaccine,Vaccine, Viral,Vaccines, Viral
D015164 Vaccines, Inactivated Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins. Inactivated Vaccine,Killed Vaccine,Killed Vaccines,Vaccines, Killed,Inactivated Vaccines,Vaccine, Inactivated,Vaccine, Killed
D016181 Feline Acquired Immunodeficiency Syndrome Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV). AIDS, Feline,FAIDS,Feline AIDS,Feline Acquired Immune Deficiency Syndrome,Feline Acquired Immuno-Deficiency Syndrome,Feline Acquired Immuno Deficiency Syndrome
D046010 Tigers The species Panthera tigris, a large feline inhabiting Asia. Several subspecies exist including the Siberian tiger and Sumatran tiger. Panthera tigris,Tiger
D028301 Feline Panleukopenia Virus A species of PARVOVIRUS infecting cats with a highly contagious enteric disease. Host range variants include mink enteritis virus, canine parvovirus (PARVOVIRUS, CANINE), and raccoon parvovirus. After infecting their new hosts, many of these viruses have further evolved and are now considered distinct species. FPLV,Feline Infectious Enteritis Virus,Infectious Enteritis Virus, Feline,Feline Parvovirus,Panleukopenia Virus of Cats,Parvovirus, Feline,Feline Panleukopenia Viruses,Feline Parvoviruses,Panleukopenia Virus, Feline,Panleukopenia Viruses, Feline,Parvoviruses, Feline,Virus, Feline Panleukopenia,Viruses, Feline Panleukopenia

Related Publications

Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
December 1987, Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
December 1970, Journal of the American Veterinary Medical Association,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
June 1972, Journal of the American Veterinary Medical Association,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
July 1973, The Journal of small animal practice,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
January 1982, The Cornell veterinarian,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
June 1956, Journal of the American Veterinary Medical Association,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
March 1970, Veterinary medicine, small animal clinician : VM, SAC,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
October 1975, Nihon juigaku zasshi. The Japanese journal of veterinary science,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
April 1978, Pediatrics,
Yali Yu, and Ming Zhou, and Jin Zhang, and Yuping Hua, and Ligang Wang, and Yinan Liu, and Dan Liu, and Xianzhu Xia
August 1978, Pediatrics,
Copied contents to your clipboard!