-transparent.png){kind=logo}
The postnatal development of [3H]thienylphencyclidine ([3H]TCP) sites in rat hippocampus has been studied autoradiographically and with membrane preparations. [3H]TCP binding increased progressively from birth to adulthood; this is due to a change in the maximal number of sites (Bmax) but not in the affinity (Kd). A different developmental pattern was found for strychnine-insensitive [3H]glycine binding which also increased after birth, but reached adult levels earlier than [3H]TCP binding. The ontogenesis of TCP or glycine sites also differed from that previously described for N-methyl-D-aspartate (NMDA) sites in the hippocampus. In neonatal, as in adult hippocampus, [3H]TCP binding was enhanced by NMDA or glycine and reduced by Mg2+. We suggest that TCP sites are functionally coupled to the NMDA receptor-ion channel complex in developing as in mature hippocampus, but that there are developmental changes in the receptor channel complex.
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
January 1987,
Neuroscience letters,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
November 1989,
Neuroscience letters,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
September 1998,
Anatomy and embryology,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
March 1989,
Brain research,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
June 1991,
Neuroscience letters,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
July 1986,
European journal of pharmacology,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
December 1987,
Neuroscience letters,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
January 1989,
Neuroscience,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
February 1984,
European journal of pharmacology,
E Tremblay, and
M P Roisin-Lallemand, and
Y Ben-Ari
September 1987,
European journal of pharmacology,
