Biomaterial Database

[Phonophoresis of the proteolytic enzymes lekozim or kollalizin in the combined therapy of eye burns]. 1990

S A Iakimenko, and R I Chalanova

A two-stage phonophoresis of proteolytic enzymes of lecozim or collalysine was used in a complex treatment of severe eye burns. The main group of patients consisted of 20 patients (23 eyes) treated by lecozim phonophoresis and 6 patients (6 eyes)--by collalysine phonophoresis. The control group consisted of 23 patients (25 eyes) treated by a complex treatment without phonophoresis of proteolytic enzymes. The comparative analysis of the course of a burn disease in both groups has shown positive influence of enzyme therapy on its dynamics and outcome. In the main group, the arrest of inflammatory signs accomplished earlier (by the 27th-29th day) as compared with the control group (by the 32nd-38th day) as well as epithelialization of corneal defects (by the 27th-30th day and by the 34th-42nd day, respectively); earlier vascularization of the cornea stimulated improvement of the burn process. Of a characteristic feature of the treatment was resolution of corneal opacification that began already after the first stage and continued within the second stage of the treatment. This allowed to achieve higher functional results. In the main group, visual acuity rose in 88.5%, and in the control--in 48% of patients.

UI	MeSH Term	Description	Entries
D010206	Papain	A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.	Tromasin
D010447	Peptide Hydrolases	Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.	Peptidase,Peptidases,Peptide Hydrolase,Protease,Proteases,Proteinase,Proteinases,Proteolytic Enzyme,Proteolytic Enzymes,Esteroproteases,Enzyme, Proteolytic,Hydrolase, Peptide
D002917	Chymopapain	A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.	Chemolase,Chymodiactin,Chymopapain A,Chymopapain B,Discase
D003012	Microbial Collagenase	A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.	Clostridiopeptidase A,Clostridium histolyticum Collagenase,Collagenase, Microbial,Collagenase Clostridium histolyticum,Collagenase-Like Peptidase,Collalysine,Nucleolysin,Clostridium histolyticum, Collagenase,Collagenase Like Peptidase,Collagenase, Clostridium histolyticum,Peptidase, Collagenase-Like,histolyticum, Collagenase Clostridium
D003131	Combined Modality Therapy	The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.	Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005126	Eye Burns	Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.	Burn, Eye,Burns, Eye,Eye Burn
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor