BIOMAT Database Logo BIOMAT Database Logo

Neuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves. 2009

Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
The Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou, PR China.

BACKGROUND Flavonoids, extracted from the leaves of Diospyros kaki, are the main therapeutic components of NaoXingQing (NXQ), a potent and patented Chinese herbal remedy widely used in China for the treatment of apoplexy syndrome. OBJECTIVE To investigate the neuroprotective effects of FLDK-P70, a standardized flavonoid extract, using in vivo rat models of both focal ischemia/reperfusion (I/R) injury induced by middle cerebral artery occlusion (MCAO) and on transient global brain ischemia induced by four-vessel occlusion (4-VO). We also aim to examine the effects of FLDK-P70 on glutamate-induced cell injury of hippocampal neurons as well as on hypoxia-induced injury of cortical neurons in primary cell culture. RESULTS Administration of FLDK-P70 for 12 days (40, 80 mg/kg body weight, p.o., 5 days before and 7 days after 4-VO) increased the survival of hippocampal CA1 pyramidal neurons after transient global brain ischemia. Similarly, administration of FLDK-P70 for 7 days (40, 80 mg/kg body weight, p.o., 3 days before and 4 days after MCAO) significantly reduced the lesion of the insulted brain hemisphere and improved the neurological behavior of rats. In primary rat hippocampal neuronal cultures, pretreatment with FLDK-P70 (5, 10 microg/ml) protected neurons from glutamate-induced excitotoxic neuronal death in a dose-dependent manner. In primary rat cerebral cortical neuronal culture, pretreatment with FLDK-P70 (25, 100 microg/ml) also reduced hypoxia-reoxygen induced neuronal death and apoptosis in a dose-dependent manner. CONCLUSIONS These in vivo and in vitro results suggest that FLDK-P70 significantly protects rats from MCAO and 4-VO ischemic injury in vivo and protects hippocampal neurons from glutamate-induced excitotoxic injury as well as cortical neurons from hypoxia-induced injury in vitro. The mechanisms of these effects may be due to the antioxidative activity of the flavonoids. These results convincingly demonstrate that FLDK-P70 may be useful for the prevention and treatment of ischemia/reperfusion injury and other related neurodegenerative diseases.

UI MeSH Term Description Entries
D008297 Male Males
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D002546 Ischemic Attack, Transient Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6) Brain Stem Ischemia, Transient,Cerebral Ischemia, Transient,Crescendo Transient Ischemic Attacks,Transient Ischemic Attack,Anterior Circulation Transient Ischemic Attack,Brain Stem Transient Ischemic Attack,Brain TIA,Brainstem Ischemia, Transient,Brainstem Transient Ischemic Attack,Carotid Circulation Transient Ischemic Attack,Posterior Circulation Transient Ischemic Attack,TIA (Transient Ischemic Attack),Transient Ischemic Attack, Anterior Circulation,Transient Ischemic Attack, Brain Stem,Transient Ischemic Attack, Brainstem,Transient Ischemic Attack, Carotid Circulation,Transient Ischemic Attack, Posterior Circulation,Transient Ischemic Attack, Vertebrobasilar Circulation,Transient Ischemic Attacks, Crescendo,Vertebrobasilar Circulation Transient Ischemic Attack,Attack, Transient Ischemic,Attacks, Transient Ischemic,Brainstem Ischemias, Transient,Cerebral Ischemias, Transient,Ischemia, Transient Brainstem,Ischemia, Transient Cerebral,Ischemias, Transient Brainstem,Ischemias, Transient Cerebral,Ischemic Attacks, Transient,TIA, Brain,TIAs (Transient Ischemic Attack),Transient Brainstem Ischemia,Transient Cerebral Ischemia,Transient Cerebral Ischemias,Transient Ischemic Attacks
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005419 Flavonoids A group of phenyl benzopyrans named for having structures like FLAVONES. 2-Phenyl-Benzopyran,2-Phenyl-Chromene,Bioflavonoid,Bioflavonoids,Flavonoid,2-Phenyl-Benzopyrans,2-Phenyl-Chromenes,2 Phenyl Benzopyran,2 Phenyl Benzopyrans,2 Phenyl Chromene,2 Phenyl Chromenes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015427 Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA. Ischemia-Reperfusion Injury,Injury, Ischemia-Reperfusion,Injury, Reperfusion,Reperfusion Damage,Damage, Reperfusion,Injury, Ischemia Reperfusion,Ischemia Reperfusion Injury,Ischemia-Reperfusion Injuries,Reperfusion Damages,Reperfusion Injuries
D016923 Cell Death The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability. Death, Cell
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats

Related Publications

Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Triterpene saponins with neuroprotective effects from the leaves of Diospyros kaki Thunb.
September 2018, Fitoterapia,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Therapeutic effects of a standardized-flavonoid Diospyros kaki L.f. leaf extract on transient focal cerebral ischemia-induced brain injury in mice.
June 2023, Journal of natural medicines,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Hypotensive principles of Diospyros kaki leaves.
November 1979, Chemical & pharmaceutical bulletin,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
A novel C-glycosylflavone from the leaves of Diospyros kaki.
June 2009, Journal of Asian natural products research,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration.
April 2017, Scientific reports,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves.
October 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Kakispyrol, a new biphenyl derivative from the leaves of Diospyros kaki.
June 2005, Journal of Asian natural products research,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Three minor novel triterpenoids from the leaves of Diospyros kaki.
May 2009, Chemical & pharmaceutical bulletin,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Flavonoid-Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D-Galactose-Induced Oxidative Stress and Neuroinflammation-Mediated Brain Aging in Mice.
January 2018, Oxidative medicine and cellular longevity,
Weijian Bei, and Linquan Zang, and Jiao Guo, and Wenlie Peng, and Anlong Xu, and David A Good, and Yinming Hu, and Wei Wu, and Dehui Hu, and Xinghong Zhu, and Ming Wei, and Chuyuan Li
Structural analysis of a pectic polysaccharide from the leaves of Diospyros kaki.
March 2004, Phytochemistry,
Copied contents to your clipboard!