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The biological characteristics of a line of stress-sensitive hypertensive (SSH) rats genetically selected from Wistar rats are described, in particular the dynamics of arterial blood pressure and the biochemical properties of the Na(+)-K+ ATPase present in the outer renal medulla. Changes in the specific activity of this enzyme are discussed in terms of the lipid composition of the membrane bilayer and the amount of endogenous ouabain-like compounds present in the blood of the animals under study. Rats of both strains, Wistar and SSH, were studied under conditions of rest and stress (8 day regime of daily 30 min immobilization). The production in vivo of adrenal mineralocorticoids and glucocorticoids is estimated and several biochemical features of the pathogenesis of essential hypertension are discussed.
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The American journal of the medical sciences,
A A Boldyrev, and
A A Kamernitskii, and
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A L Markel'
May 1995,
Chinese medical journal,
A A Boldyrev, and
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January 1992,
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A A Boldyrev, and
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A A Boldyrev, and
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November 1995,
Biulleten' eksperimental'noi biologii i meditsiny,
A A Boldyrev, and
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January 2005,
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A A Boldyrev, and
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February 2015,
Bulletin of experimental biology and medicine,
A A Boldyrev, and
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December 2003,
American journal of hypertension,
A A Boldyrev, and
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May 2017,
Experimental physiology,
A A Boldyrev, and
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A L Markel'
August 2003,
Clinical and experimental pharmacology & physiology,
