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A dependence of activity of histidase from rat liver and skin on the agents affecting the activity of the adenylate cyclase systeme was studied in vitro. Under conditions optimal for the activity of liver phosphorylase protein kinase the skin extract histidase was activated 2-3-fold. This is indicative of a possibility of regulation of the skin histidase activity via the adenylate cyclase system by modification of enzyme by phosphorylation-dephosphorylation, which is performed by 3':5'-AMP-dependent protein kinase. Theophylline at concentrations of 10(-4) M and 10(-3) M activates partially purified histidase (both liver and skin forms), probably in the course of direct interaction with the enzyme.
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
August 1971,
Endocrinology,
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
December 1974,
The Journal of investigative dermatology,
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
January 1976,
Voprosy meditsinskoi khimii,
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
January 1976,
Voprosy meditsinskoi khimii,
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
August 1968,
Cancer research,
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
April 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
November 1990,
Biokhimiia (Moscow, Russia),
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
July 1979,
Archives of biochemistry and biophysics,
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
March 1969,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
A Ia Nikolaev, and
E V Osipov, and
V A Burobin, and
E A Kozlov
June 1975,
Proceedings of the National Academy of Sciences of the United States of America,
