BIOMAT Database Logo BIOMAT Database Logo

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment. 2009

Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Assistance publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de Néphrologie Pédiatrique, Paris, France. valerie.leroy@unige.ch

Although steroid-free remission can usually be achieved with cyclosporin A (CsA) in patients with steroid-dependent nephrotic syndrome (SDNS), some CsA-treated patients require long-term steroid therapy. Data on growth in these patients are scarce. Sixty-four boys with SDNS receiving long-term CsA and steroid therapy were retrospectively analyzed. During the 10-year follow-up period, height standard deviation score (HSDS) remained in the normal range in 47 patients but was below -2 SD in 17 patients. The occurrence of growth retardation was influenced by height at diagnosis and the number of relapses. Thirty patients were followed for at least 3 years before and after age 12. The decrease in HSDS per year of disease in patients older than 12 years was twice that observed in children younger than 12. However, adult height was < or = -2 SD in only two of the 14 patients reaching adult height, reflecting potential catch-up growth during late puberty. Careful monitoring of growth is recommended, given than up to 25% of patients experienced severe growth retardation during the course of their disease.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D008137 Longitudinal Studies Studies in which variables relating to an individual or group of individuals are assessed over a period of time. Bogalusa Heart Study,California Teachers Study,Framingham Heart Study,Jackson Heart Study,Longitudinal Survey,Tuskegee Syphilis Study,Bogalusa Heart Studies,California Teachers Studies,Framingham Heart Studies,Heart Studies, Bogalusa,Heart Studies, Framingham,Heart Studies, Jackson,Heart Study, Bogalusa,Heart Study, Framingham,Heart Study, Jackson,Jackson Heart Studies,Longitudinal Study,Longitudinal Surveys,Studies, Bogalusa Heart,Studies, California Teachers,Studies, Jackson Heart,Studies, Longitudinal,Study, Bogalusa Heart,Study, California Teachers,Study, Longitudinal,Survey, Longitudinal,Surveys, Longitudinal,Syphilis Studies, Tuskegee,Syphilis Study, Tuskegee,Teachers Studies, California,Teachers Study, California,Tuskegee Syphilis Studies
D008297 Male Males
D009404 Nephrotic Syndrome A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction. Childhood Idiopathic Nephrotic Syndrome,Frequently Relapsing Nephrotic Syndrome,Multi-Drug Resistant Nephrotic Syndrome,Pediatric Idiopathic Nephrotic Syndrome,Steroid-Dependent Nephrotic Syndrome,Steroid-Resistant Nephrotic Syndrome,Steroid-Sensitive Nephrotic Syndrome,Multi Drug Resistant Nephrotic Syndrome,Nephrotic Syndrome, Steroid-Dependent,Nephrotic Syndrome, Steroid-Resistant,Nephrotic Syndrome, Steroid-Sensitive,Nephrotic Syndromes,Steroid Dependent Nephrotic Syndrome,Steroid Resistant Nephrotic Syndrome,Steroid Sensitive Nephrotic Syndrome,Steroid-Dependent Nephrotic Syndromes,Steroid-Resistant Nephrotic Syndromes,Steroid-Sensitive Nephrotic Syndromes,Syndrome, Nephrotic,Syndrome, Steroid-Sensitive Nephrotic
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D001827 Body Height The distance from the sole to the crown of the head with body standing on a flat surface and fully extended. Body Heights,Height, Body,Heights, Body
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006128 Growth Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.

Related Publications

Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Long-term cyclosporin in steroid-dependent nephrotic syndrome.
January 1995, Contributions to nephrology,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Cyclosporin in steroid-resistant idiopathic nephrotic syndrome.
January 1995, Contributions to nephrology,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Treatment of idiopathic nephrotic syndrome with cyclosporin in children. Preliminary results of growth data in long-term use.
April 1992, Journal of autoimmunity,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Long-term steroid treatment and growth: a study in steroid-dependent nephrotic syndrome.
February 2010, Archives of disease in childhood,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Long-term outcome of children with steroid-sensitive idiopathic nephrotic syndrome.
October 2009, Clinical journal of the American Society of Nephrology : CJASN,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Long-term results of steroid therapy in adults with idiopathic nephrotic syndrome.
June 1969, The American journal of medicine,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Long-term cyclosporin A treatment in adults with refractory nephrotic syndrome.
November 1995, Renal failure,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
[Treatment of idiopathic nephrotic syndrome with cyclosporin A].
September 1997, Anales espanoles de pediatria,
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Long-term outcome of idiopathic steroid-resistant nephrotic syndrome in children.
March 2016, Pediatric nephrology (Berlin, Germany),
Valérie Leroy, and Véronique Baudouin, and Corinne Alberti, and Geneviève Guest, and Patrick Niaudet, and Chantal Loirat, and Georges Deschenes, and Paul Czernichow, and Dominique Simon
Treatment with cyclosporin of patients with idiopathic nephrotic syndrome.
January 1987, Springer seminars in immunopathology,
Copied contents to your clipboard!