BIOMAT Database Logo BIOMAT Database Logo

A cross-sectional observation of effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. 2009

Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, Nagano 390-8621, Japan.

This study was aimed at clarifying the effect of exposure to N-methyl-2-pyrrolidone (NMP) on workers' health. Fifteen male NMP-exposed workers and 15 referent male workers were recruited for this study. Exposure concentrations were assessed by determining NMP in the breathing zones and urinary NMP. Clinical examinations, motor and sensory nerve conduction velocities in the dominant arm, and neurobehavioral tests were carried out. The subjects were asked to complete self-administered questionnaires for subjective symptoms and psychological assessment. The mean NMP exposure concentrations ranged from 0.14 to 0.26 ppm, and urinary NMP levels at the end of each workday ranged from 0.17 to 0.22 mg/l, throughout the work week. In terms of clinical data, motor and sensory nerve conduction velocities, neurobehavioral tests, and subjective symptom assessments, there were no differences and no dose-dependent changes in either the means or the prevalence of abnormal findings between NMP-exposed and referent workers.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011760 Pyrrolidinones A group of compounds that are derivatives of oxo-pyrrolidines. A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck Index, 11th ed) Pyrrolidinone,Pyrrolidone,Pyrrolidones
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013723 Teratogens An agent that causes the production of physical defects in the developing embryo. Embryotoxins,Fetotoxins,Teratogen
D016273 Occupational Exposure The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation. Exposure, Occupational,Exposures, Occupational,Occupational Exposures

Related Publications

Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Chemosensory effects during acute exposure to N-methyl-2-pyrrolidone (NMP).
December 2007, Toxicology letters,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Irritant cutaneous reactions to N-methyl-2-pyrrolidone (NMP).
September 1992, Contact dermatitis,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy- N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy- N-methylsuccinimide (2-HMSI), and biological monitoring using 2-HMSI as a biomarker.
May 2003, International archives of occupational and environmental health,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Biological monitoring and health effects of low-level exposure to N-methyl-2-pyrrolidone: a cross-sectional study.
August 2014, International archives of occupational and environmental health,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): acute effects and pharmacokinetics of NMP in plasma and urine.
April 1997, Occupational and environmental medicine,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Local Structure and Polar Order in Liquid N-Methyl-2-pyrrolidone (NMP).
September 2018, The journal of physical chemistry. B,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Biomonitoring of exposure to N-methyl-2-pyrrolidone in workers of the automobile industry.
July 2013, The Annals of occupational hygiene,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Salt Effect on the Isobaric Vapor-Liquid Equilibrium Study of Binary Mixtures H2O-NMP (N-Methyl-2-pyrrolidone).
December 2020, ACS omega,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Human volunteer study on the influence of exposure duration and dilution of dermally applied N-methyl-2-pyrrolidone (NMP) on the urinary elimination of NMP metabolites.
February 2007, International archives of occupational and environmental health,
Shigeru Nishimura, and Hirohiko Yasui, and Hiroyuki Miyauchi, and Yuriko Kikuchi, and Nami Kondo, and Toru Takebayashi, and Shigeru Tanaka, and Yuko Mikoshiba, and Kazuyuki Omae, and Tetsuo Nomiyama
Stillbirth after occupational exposure to N-methyl-2 pyrrolidone.
May 1997, Journal of occupational and environmental medicine,
Copied contents to your clipboard!