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Selective reduction was carried out in 46 multifetal pregnancies by means of potassium chloride injection into the pericardial region of the fetus. There were three indications for the procedure: to improve perinatal outcome and to increase the likelihood that a term infant would be born in a multifetal pregnancy (34 women); to allow the birth of a healthy infant without the birth of a congenitally abnormal coexisting fetus (8 women); and to preserve a singleton pregnancy when the woman would otherwise have the whole pregnancy terminated (4 women). Of the 80 fetuses left after reduction 75 (94%) have survived. In 3 cases ultrasound scanning showed cardiac activity in the injected fetus 20-30 min after the initial injection despite 2 min of asystole immediately after the injection; repeated injection, carried out the same day, led to fetal death in all 3 cases. Selective reduction of multifetal pregnancies for the three indications described is an ethically justifiable option for the management of multifetal pregnancy, to which there are no public policy obstacles.
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
October 1988,
The New England journal of medicine,
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
August 1995,
Zhonghua yi xue za zhi,
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
April 1988,
The New England journal of medicine,
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
May 1992,
Fertility and sterility,
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
April 1993,
Human reproduction (Oxford, England),
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
October 1996,
American journal of obstetrics and gynecology,
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
February 1991,
European journal of obstetrics, gynecology, and reproductive biology,
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
November 1990,
Human reproduction (Oxford, England),
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
December 1995,
Current opinion in obstetrics & gynecology,
R J Wapner, and
G H Davis, and
A Johnson, and
V J Weinblatt, and
R L Fischer, and
L G Jackson, and
F A Chervenak, and
L B McCullough
June 1999,
Middle East journal of anaesthesiology,
