-transparent.png){kind=logo}
Tiazofurin and retinoic acid synergistically induced differentiation and inhibited colony formation in HL-60 human promyelocytic leukemia cells in cell culture. The synergism was the result of different mechanisms of action, since the effect of tiazofurin, unlike that of retinoic acid, was prevented by addition of guanosine. Since it has been shown that tiazofurin down-regulated the expression of c-Ki-ras oncogene, and retinoic acid that of the myc oncogene, the joint impact of these drugs is of clinical interest particularly in end-stage leukemia where the therapeutic usefulness of tiazofurin has recently been demonstrated.
Related Publications
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
June 1998,
European journal of pharmacology,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
May 1989,
Experimental cell research,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
May 1985,
Cancer research,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
August 1990,
Environmental health perspectives,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
March 2005,
Experimental hematology,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
January 2000,
Experimental cell research,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
November 2008,
Nutrition research (New York, N.Y.),
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
December 1994,
Blood,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
July 1991,
Biochemical and biophysical research communications,
Y Yamaji, and
Y Natsumeda, and
Y Yamada, and
S Irino, and
G Weber
December 2018,
Leukemia & lymphoma,
