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To test the hypothesis that increments in plasma cyclic AMP during beta-adrenergic stimulation reflect integrated second messenger function of the tissues activated by the agonist, graded adrenaline infusion resulting in plasma adrenaline concentrations within the physiological range was performed in 8 healthy subjects with and without concomitant beta-adrenoceptor blockade by iv propranolol. A significant correlation was found between increments in plasma adrenaline and plasma cyclic AMP in the experiments without beta-blockade; during concomitant beta-blockade the increase in plasma cyclic AMP concentrations at low adrenaline infusion rates was prevented, whereas a small increase in cyclic AMP was found at high adrenaline infusion rates, probably owing to incomplete beta-receptor blockade. Likewise, the adrenaline-induced increments in blood substrates (glucose, lactate, glycerol and beta hydroxybutyric acid) were significantly reduced but not completely prevented by beta-blockade. We conclude that an altered relationship between beta-agonist concentrations and plasma cyclic AMP may provide evidence for the existence of differences in beta-adrenergic sensitivity in man.
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
September 1977,
Scandinavian journal of clinical and laboratory investigation,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
October 1976,
International journal of clinical pharmacology and biopharmacy,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
May 1977,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
March 1978,
The British journal of surgery,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
March 1991,
British journal of pharmacology,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
June 1978,
Chest,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
June 1986,
Journal of leukocyte biology,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
January 1981,
The Journal of international medical research,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
January 1991,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
E K Philipsen, and
J Myhre, and
S Larsen, and
M Damkjaer Nielsen, and
J J Holst, and
J Hilsted
January 1994,
Zeitschrift fur Geburtshilfe und Perinatologie,
