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Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition. 1990
M Polydefkis, and
S Koenig, and
C Flexner, and
E Obah, and
K Gebo, and
S Chakrabarti, and
P L Earl, and
B Moss, and
R F Siliciano
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Human CD4+ T cell clones and cell lines were shown to lyse recombinant vaccinia virus-infected cells that synthesize the HIV-1 envelope glycoprotein gp160. The processing of endogenously synthesized gp160 for recognition by CD4+ T cells required that the protein, after synthesis on the rough endoplasmic reticulum and during subsequent cellular transport, remain attached to the luminal/extracellular membrane face by a hydrophobic anchor sequence.
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