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Transposition of the maize transposable elements Ac, Spm and Mu is correlated with a lack of methylation. For both Ac (Schwartz & Dennis 1986) and Spm (Fedoroff et al. 1988) methylation of a region upstream and downstream of the site of initiation of transcription results in a loss both of mRNA encoding for the transposase and the ability to excise. We have studied the activation of an inactive, methylated derivative of Ac by using a cycle of tissue culture. A passage through tissue culture results in activation of the element and is correlated with demethylation of the 5' end of the transposase gene. Demethylation and activation may occur as a multistep process. We propose a model in which binding of the Ac transposase to the 5' region of the Ac element prevents methylation following replication. Consequently, demethylation and reactivation occurs.
E S Dennis, and
R I Brettell
January 1995,
Current topics in microbiology and immunology,
E S Dennis, and
R I Brettell
October 2010,
BMC genomics,
E S Dennis, and
R I Brettell
December 2019,
Essays in biochemistry,
E S Dennis, and
R I Brettell
June 2010,
BMC genomics,
E S Dennis, and
R I Brettell
January 1994,
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik,
E S Dennis, and
R I Brettell
April 2018,
Plant physiology,
E S Dennis, and
R I Brettell
November 2012,
Current opinion in plant biology,
E S Dennis, and
R I Brettell
January 1984,
Cold Spring Harbor symposia on quantitative biology,
