OBJECTIVE The aim of the present study was to report the experience of 40 patients who had undergone intraoral verticosagittal ramus osteotomy (IVSRO) to treat dentofacial deformities. METHODS The charts of 40 consecutive patients who had undergone IVSRO were analyzed regarding the diagnosis, amount of mandibular movement, and complications. RESULTS Eighty IVSROs were performed in 40 patients. The mean follow-up was 18 months. Mandibular protrusion in both genders was the main preoperative diagnosis (25 patients), and the treatment was 2-jaw surgery in 36 patients. The mean amount of movement was 2 mm for the mandible setback and advancement, 3 mm for mandible counterclockwise rotations, and 2 mm for mandible clockwise rotations. The mean period of maxillomandibular fixation was 15 days, followed by a period of heavy elastics. The rate of complications was 2%, including 2 bad splits, and 2 cases of intraoperative bleeding. No nerve injury was observed in the 40 patients studied. CONCLUSIONS The IVSRO is efficient and versatile, with low morbidity, and is an option for the oral and maxillofacial surgeon to treat patients with mandibular dentoskeletal discrepancies.