Biomaterial Database

Surgical hand disinfection: comparison of 4% chlorhexidine detergent solution and 2% triclosan detergent solution. 1990

J W Bendig

Department of Medical Microbiology, St George's Hospital, London.

The effect of 4% chlorhexidine detergent and 2% triclosan detergent on the resident flora of the hands was compared on 20 healthy volunteers. The initial and prolonged effects of the agents were assessed by a modification of the Peterson glove rinse test after multiple hand washes. Chlorhexidine detergent was significantly more effective than triclosan detergent (p less than 0.001) which in turn was more effective than non-medicated soap (p less than 0.001) for both initial and prolonged effect. Chlorhexidine, but not triclosan, showed a significantly greater prolonged effect than initial effect (p less than 0.01). Five volunteers (25%) experienced skin irritation with triclosan; no side effects were experienced with chlorhexidine.

UI	MeSH Term	Description	Entries
D010647	Phenyl Ethers	Ethers that are linked to a benzene ring structure.	Diphenyl Oxide,Diphenyl Oxides,Diphenyl Ethers,Ethers, Diphenyl,Ethers, Phenyl,Oxide, Diphenyl,Oxides, Diphenyl
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D002710	Chlorhexidine	A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.	Chlorhexidine Acetate,Chlorhexidine Hydrochloride,MK-412A,Novalsan,Sebidin A,Tubulicid,Acetate, Chlorhexidine,Hydrochloride, Chlorhexidine,MK 412A,MK412A
D004202	Disinfectants	Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)	Biocide,Disinfectant,Biocides
D006225	Hand	The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.	Hands
D006235	Hand Disinfection	The act of cleansing the hands with water or other liquid, with or without the inclusion of soap or other detergent, for the purpose of destroying infectious microorganisms.	Disinfection, Hand,Handwashing,Hand Sanitization,Hand Washing,Scrubbing, Surgical,Surgical Scrubbing,Hand Washings,Sanitization, Hand,Washing, Hand,Washings, Hand
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013530	Surgical Wound Infection	Infection occurring at the site of a surgical incision.	Postoperative Wound Infection,Infection, Postoperative Wound,Infection, Surgical Wound,Surgical Site Infection,Wound Infection, Postoperative,Wound Infection, Surgical,Infection, Surgical Site,Infections, Postoperative Wound,Infections, Surgical Site,Infections, Surgical Wound,Postoperative Wound Infections,Surgical Site Infections,Surgical Wound Infections,Wound Infections, Postoperative,Wound Infections, Surgical
D014260	Triclosan	A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.	2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether,2-Hydroxy-2',4,4'-trichlorodiphenyl Ether,Aquasept,Clearasil Daily Face Wash,Cliniclean,Irgasan DP 300,Irgasan DP300,Irgasan-DP300,Manusept,Microshield T,Oxy Skin Wash,Sapoderm,Ster-Zac Bath Concentrate,Tersaseptic,Trisan,pHisoHex,DP300, Irgasan,Ster Zac Bath Concentrate,SterZac Bath Concentrate
D015169	Colony Count, Microbial	Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.	Agar Dilution Count,Colony-Forming Units Assay, Microbial,Fungal Count,Pour Plate Count,Spore Count,Spread Plate Count,Streak Plate Count,Colony Forming Units Assay, Microbial,Colony Forming Units Assays, Microbial,Agar Dilution Counts,Colony Counts, Microbial,Count, Agar Dilution,Count, Fungal,Count, Microbial Colony,Count, Pour Plate,Count, Spore,Count, Spread Plate,Count, Streak Plate,Counts, Agar Dilution,Counts, Fungal,Counts, Microbial Colony,Counts, Pour Plate,Counts, Spore,Counts, Spread Plate,Counts, Streak Plate,Dilution Count, Agar,Dilution Counts, Agar,Fungal Counts,Microbial Colony Count,Microbial Colony Counts,Pour Plate Counts,Spore Counts,Spread Plate Counts,Streak Plate Counts