Biomaterial Database

The in vitro elution characteristics of vancomycin from calcium phosphate-calcium sulfate beads. 2009

Brandon M Scharer, and Shawn M Sanicola

Wheaton Franciscan Healthcare, Milwaukee, WI 53222, USA. Brandon.Scharer@dmu.edu

The purpose of this study was to determine the elution characteristics of vancomycin when combined with a calcium phosphate-calcium sulfate mixture to form antibiotic beads in an in vitro environment. The beads were placed in phosphate-buffered saline and kept at 36 degrees C for 6 weeks. Three separate assays were undertaken, after which the phosphate-buffered saline was assayed at 24-hour intervals. Elution of the antibiotic was sustained at a gradual rate for 22 days. The amount of vancomycin assayed nearly equaled the calculated amount of antibiotic per bead measured during bead construction. In conclusion, calcium phosphate-calcium sulfate composite beads, when combined with vancomycin, elute vancomycin in a gradual and sustained fashion for 22 days in vitro. METHODS 2.

UI	MeSH Term	Description	Entries
D002130	Calcium Phosphates	Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.	Phosphates, Calcium
D002133	Calcium Sulfate	A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.	Dental Gypsum,Dental Stone, Artificial,Gypsum,Plaster of Paris,Alabaster,Anhydrous Sulfate of Lime,Artificial Dental Stone,Calcium Sulfate (1:1), Dihydrate,Calcium Sulfate (1:1), Hemihydrate,Calcium Sulfate (2:1),Calcium Sulfate Dihydrate,Calcium Sulfate, Anhydrous,Calcium Sulfate, Dihydrate,Calcium Sulfate, Hemihydrate,Calcium Sulphate,Drierite,Gypsite,Gypsum, Dental,Karstenite,Stone, Artificial Dental
D003764	Dental Materials	Materials used in the production of dental bases, restorations, impressions, prostheses, etc.	Dental Material,Material, Dental,Materials, Dental
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000900	Anti-Bacterial Agents	Substances that inhibit the growth or reproduction of BACTERIA.	Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D014640	Vancomycin	Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.	AB-Vancomycin,Diatracin,VANCO-cell,Vanco Azupharma,Vanco-saar,Vancocin,Vancocin HCl,Vancocine,Vancomicina Abbott,Vancomicina Chiesi,Vancomicina Combino Phar,Vancomicina Norman,Vancomycin Hexal,Vancomycin Hydrochloride,Vancomycin Lilly,Vancomycin Phosphate (1:2),Vancomycin Phosphate (1:2), Decahydrate,Vancomycin Sulfate,Vancomycin-ratiopharm,Vancomycine Dakota,Hydrochloride, Vancomycin,Sulfate, Vancomycin
D016503	Drug Delivery Systems	Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.	Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In