BIOMAT Database Logo BIOMAT Database Logo

Transient tyrosine hydroxylase-immunoreactive neurons in the region of the anterior olfactory nucleus of pre- and postnatal mice do not contain dopamine. 1990

I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Department of Anatomy, School of Medicine, Fujita-Gakuen Health University, Toyoake, Japan.

The transient appearance of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons in the anterior olfactory nuclear region of mice was investigated using TH-immunocytochemistry. In this region, a new cell group composed of a small number of neurons immunoreactive to TH was demonstrated for the first time from the embryonic stages of E16-E18. These cells were not shown using antisera against aromatic L-amino acid decarboxylase, dopamine-beta-hydroxylase, phenylethanolamine-N-methyl-transferase, dopamine or serotonin. TH-IR cells progressively increased in number until birth. After birth the numbers reached maximum at postnatal days 9-12 and decreased until 4 weeks old, and then mostly disappeared at 6 weeks. Only single TH-IR cells were occasionally observed in this brain area of adult mice. Ultrastructurally some of these TH-IR neurons had immature Golgi apparatus, only a few mitochondria and deformed nuclei along with thin cytoplasma. Some other TH-IR cells, however, had mature Golgi apparatus, many mitochondria and a round nucleus more closely resembling mature cells. These neurons do not belong to the dopaminergic neuron system, because they lack dopamine production, and may be tentatively involved in early limbic circuits.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D009830 Olfactory Bulb Ovoid body resting on the CRIBRIFORM PLATE of the ethmoid bone where the OLFACTORY NERVE terminates. The olfactory bulb contains several types of nerve cells including the mitral cells, on whose DENDRITES the olfactory nerve synapses, forming the olfactory glomeruli. The accessory olfactory bulb, which receives the projection from the VOMERONASAL ORGAN via the vomeronasal nerve, is also included here. Accessory Olfactory Bulb,Olfactory Tract,Bulbus Olfactorius,Lateral Olfactory Tract,Main Olfactory Bulb,Olfactory Glomerulus,Accessory Olfactory Bulbs,Bulb, Accessory Olfactory,Bulb, Main Olfactory,Bulb, Olfactory,Bulbs, Accessory Olfactory,Bulbs, Main Olfactory,Bulbs, Olfactory,Glomerulus, Olfactory,Lateral Olfactory Tracts,Main Olfactory Bulbs,Olfactorius, Bulbus,Olfactory Bulb, Accessory,Olfactory Bulb, Main,Olfactory Bulbs,Olfactory Bulbs, Accessory,Olfactory Bulbs, Main,Olfactory Tract, Lateral,Olfactory Tracts,Olfactory Tracts, Lateral,Tract, Lateral Olfactory,Tract, Olfactory,Tracts, Lateral Olfactory,Tracts, Olfactory
D004298 Dopamine One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D005314 Embryonic and Fetal Development Morphological and physiological development of EMBRYOS or FETUSES. Embryo and Fetal Development,Prenatal Programming,Programming, Prenatal
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014446 Tyrosine 3-Monooxygenase An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2. Tyrosine Hydroxylase,3-Monooxygenase, Tyrosine,Hydroxylase, Tyrosine,Tyrosine 3 Monooxygenase
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Transient appearance of tyrosine hydroxylase-immunoreactive non-catecholaminergic neurons in the medial geniculate nucleus of postnatal mice.
June 1996, Neuroscience letters,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Do tyrosine hydroxylase-immunoreactive neurons in the ventrolateral arcuate nucleus produce dopamine or only L-dopa?
January 1988, Journal of chemical neuroanatomy,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Comparative topography of dopamine- and tyrosine hydroxylase-immunoreactive neurons in the rat arcuate nucleus.
December 1988, Neuroscience letters,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Dopamine-beta-hydroxylase and tyrosine hydroxylase immunoreactive neurons in the human brainstem.
April 1996, Journal of chemical neuroanatomy,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Tyrosine hydroxylase (TH)-only-immunoreactive non-catecholaminergic neurons in the brain of wild mice or the human TH transgenic mice do not contain GTP cyclohydrolase I.
May 1997, Neuroscience letters,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Transient tyrosine hydroxylase-like immunoreactive neurons contain somatostatin and substance P in the developing amygdala and bed nucleus of the stria terminalis of the rat.
July 1988, Brain research,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Morphological relationships between tyrosine hydroxylase-immunoreactive neurons and dopamine-beta-hydroxylase-immunoreactive fibres in dopamine cell group A15 of the sheep.
January 1993, Journal of chemical neuroanatomy,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Molecular phenotyping of transient postnatal tyrosine hydroxylase neurons in the rat bed nucleus of the stria terminalis.
July 2017, Journal of chemical neuroanatomy,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Development of tyrosine hydroxylase-, dopamine- and dopamine beta-hydroxylase-immunoreactive neurons in a teleost, the three-spined stickleback.
January 1992, Journal of chemical neuroanatomy,
I Nagatsu, and K Komori, and T Takeuchi, and M Sakai, and K Yamada, and N Karasawa
Development of tyrosine hydroxylase-immunoreactive neurons in the human paraventricular and supraoptic nucleus.
March 1993, Brain research. Developmental brain research,
Copied contents to your clipboard!