Biomaterial Database

Multiple sclerosis or HTLV-I myelitis? 1990

C M Poser, and G C Roman, and J C Vernant

Neurological Unit, Beth Israel Hospital, Boston, MA 02215.

Several authors have demonstrated the presence of antibodies against the HTLV-I retrovirus in patients with MS. Considerable controversy exists regarding the etiologic significance, if any, of this finding, but the presence of these antibodies in the blood or CSF of MS patients has led to reconsideration of that diagnosis in certain cases. It is recommended that, before the diagnosis of MS is changed to that of HTLV-I-associated chronic myelitis, at least 2 of the following abnormalities be present: (1) clinical or electrophysiologic involvement of peripheral nerve or muscle; (2) the presence of oligoclonal bands in the serum; (3) the presence in blood or CSF of lymphocytes with multilobed nuclei; (4) a positive serologic test for syphilis; (5) the presence of a sicca syndrome; and (6) the presence of pulmonary lymphocytic alveolitis.

UI	MeSH Term	Description	Entries
D009103	Multiple Sclerosis	An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)	MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015480	Deltaretrovirus Antibodies	Antibodies reactive with various types of human T-cell leukemia/lymphoma antigens or bovine leukemia virus antigens.	BLV Antibodies,HTLV Antibodies,HTLV-BLV Antibodies,Human T-Cell Leukemia Virus Antibodies,Leukemia Virus Antibodies, Human T-Cell,Leukemia-Lymphoma Virus Antibodies, Human T-Cell,T-Cell Leukemia-Lymphoma Virus Antibodies, Human,Human T Cell Leukemia Virus Antibodies,Leukemia Lymphoma Virus Antibodies, Human T Cell,Leukemia Virus Antibodies, Human T Cell,T Cell Leukemia Lymphoma Virus Antibodies, Human,Antibodies, BLV,Antibodies, Deltaretrovirus,Antibodies, HTLV,Antibodies, HTLV-BLV,HTLV BLV Antibodies
D015493	Paraparesis, Tropical Spastic	A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)	HTLV-I-Associated Myelopathy,Tropical Spastic Paraparesis,Familial Spastic Paraparesis, Htlv-1-Associated,HTLV I Associated Myelopathies,HTLV-I-Associated Myelopathy-Tropical Spastic Paraparesis,Human T-Lymphotropic Virus Type 1 Associated Myelopathy,Myelopathies, HTLV I Associated,Myelopathy, Htlv-1-Associated,Myelopathy, Human T-Lymphotropic Virus Type 1 Associated,Paraplegia, Tropical Spastic,Familial Spastic Paraparesis, Htlv 1 Associated,HTLV I Associated Myelopathy,HTLV I Associated Myelopathy Tropical Spastic Paraparesis,HTLV-I-Associated Myelopathies,Htlv-1-Associated Myelopathies,Htlv-1-Associated Myelopathy,Human T Lymphotropic Virus Type 1 Associated Myelopathy,Myelopathies, HTLV-I-Associated,Myelopathies, Htlv-1-Associated,Myelopathy, HTLV-I-Associated,Myelopathy, Htlv 1 Associated,Myelopathy, Human T Lymphotropic Virus Type 1 Associated,Parapareses, Tropical Spastic,Paraplegias, Tropical Spastic,Spastic Parapareses, Tropical,Spastic Paraparesis, Tropical,Spastic Paraplegia, Tropical,Spastic Paraplegias, Tropical,Tropical Spastic Parapareses,Tropical Spastic Paraplegia,Tropical Spastic Paraplegias