Biomaterial Database

Family study on Melkersson-Rosenthal syndrome. Some hereditary aspects of the disease and review of literature. 1990

M Meisel-Stosiek, and O P Hornstein, and N Stosiek

Department of Dermatology, University of Erlangen-Nürnberg, West Germany.

The medical records of 73 unrelated patients with either complete or incomplete Melkersson-Rosenthal syndrome attending our department between 1967 and 1985 were analyzed, and 42 of them as well as 171 of their relatives were examined. Lingua plicata was seen in 10, and other features were detected in 6 of the 42 families. The limited frequency of signs characteristic for the syndrome in the relatives examined suggest a multifactorial origin including a genetic basis.

UI	MeSH Term	Description	Entries
D008047	Lip Diseases	Diseases involving the LIP.	Disease, Lip,Diseases, Lip,Lip Disease
D008297	Male		Males
D008556	Melkersson-Rosenthal Syndrome	An idiopathic syndrome characterized by one or more of the following; recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue (lingua plicata). The onset is usually in childhood and relapses are common. Cheilitis granulomatosa is a monosymptomatic variant of this condition. (Dermatol Clin 1996 Apr;14(2):371-9; Magalini & Magalini, Dictionary of Medical Syndromes, 4th ed, p531)	Cheilitis Granulomatosa, Facial Neuropathy, Orofacial Edema,Granulomatous Cheilitis,Cheilitis Granulomatosa,Cheilitis Granulomatosa, Orofacial Edema, Facial Neuropathy,Facial Neuropathy, Cheilitis Granulomatosa, Orofacial Edema,Facial Neuropathy, Orofacial Edema, Cheilitis Granulomatosa,Macrocheilia, Facial Palsy, Edema,Melkerson-Rosenthal Syndrome,Melkersson Syndrome,Melkersson-Rosenthal-Miescher Syndrome,Miescher-Melkersson-Rosenthal Granulomatous Cheilitis,Orofacial Edema, Cheilitis Granulomatosa, Facial Neuropathy,Orofacial Edema, Facial Neuropathy, Cheilitis Granulomatosa,Rosenthal-Melkerson Syndrome,Rosenthal-Melkersson Syndrome,Syndrome, Melkerson Rosenthal,Cheilitis, Miescher-Melkersson-Rosenthal Granulomatous,Granulomatous Cheilitis, Miescher-Melkersson-Rosenthal,Melkerson Rosenthal Syndrome,Melkersson Rosenthal Miescher Syndrome,Melkersson Rosenthal Syndrome,Miescher Melkersson Rosenthal Granulomatous Cheilitis,Rosenthal Melkerson Syndrome,Rosenthal Melkersson Syndrome
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010375	Pedigree	The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.	Family Tree,Genealogical Tree,Genealogic Tree,Genetic Identity,Identity, Genetic,Family Trees,Genealogic Trees,Genealogical Trees,Genetic Identities,Identities, Genetic,Tree, Family,Tree, Genealogic,Tree, Genealogical,Trees, Family,Trees, Genealogic,Trees, Genealogical
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D004487	Edema	Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	Dropsy,Hydrops,Anasarca
D005158	Facial Paralysis	Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.	Facial Palsy,Hemifacial Paralysis,Facial Palsy, Lower Motor Neuron,Facial Palsy, Upper Motor Neuron,Facial Paralysis, Central,Facial Paralysis, Peripheral,Facial Paresis,Lower Motor Neuron Facial Palsy,Upper Motor Neuron Facial Palsy,Central Facial Paralyses,Central Facial Paralysis,Facial Palsies,Facial Paralyses, Central,Facial Paralyses, Peripheral,Palsies, Facial,Palsy, Facial,Paralyses, Central Facial,Paralyses, Facial,Paralyses, Hemifacial,Paralysis, Central Facial,Paralysis, Facial,Paralysis, Hemifacial,Paralysis, Peripheral Facial,Pareses, Facial,Paresis, Facial,Peripheral Facial Paralysis
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man