-transparent.png){kind=logo}
Clinically nonfunctioning pituitary adenomas are benign neoplasms comprising approximately 25-30% of pituitary tumors. Little is known about the pathogenesis of pituitary neoplasia. Clonal analysis allows one to make the important distinction between a polyclonal proliferation in response to a stimulatory factor versus a monoclonal expansion of a genetically aberrant cell. We investigated the clonal origin of pituitary tumors using X-linked restriction fragment length polymorphisms at the phosphoglycerate kinase and hypoxanthine phosphoribosyl-transferase genes. Restriction enzymes were used to distinguish maternal and paternal X-chromosomes, and combined with a methylation-sensitive restriction enzyme to analyze allelic X-inactivation patterns in six pituitary adenomas. All six tumors showed a monoclonal pattern of X-inactivation. These data indicate that nonfunctioning pituitary adenomas are unicellular in origin, a result consistent with the hypothesis that this tumor type is due to somatic mutation.
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
March 1993,
Endocrinology and metabolism clinics of North America,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
January 2014,
Handbook of clinical neurology,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
November 1987,
The Journal of clinical investigation,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
May 2014,
Journal of neuro-oncology,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
February 2010,
Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
March 2008,
Endocrinology and metabolism clinics of North America,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
February 1987,
Journal of neurosurgery,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
October 2022,
Brain tumor pathology,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
January 1995,
Endocrine pathology,
J M Alexander, and
B M Biller, and
H Bikkal, and
N T Zervas, and
A Arnold, and
A Klibanski
May 1993,
The Journal of clinical endocrinology and metabolism,
