BIOMAT Database Logo BIOMAT Database Logo

Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles. 2009

Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way No. A2A, Jupiter, Florida 33458, USA.

A general and efficient method for the preparation of 3-amino-1,2,4-triazoles has been developed. The desired 3-amino-1,2,4-triazoles (1) were prepared in good overall yield via two convergent routes. The key intermediate within both routes is substituted hydrazinecarboximidamide derivative 2.

UI MeSH Term Description Entries
D000640 Amitrole A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes. Aminotriazole,3-Amino-1,2,4-triazole
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular

Related Publications

Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Facile One-Pot Parallel Synthesis of 3-Amino-1,2,4-triazoles.
July 2018, ACS combinatorial science,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Synthesis of amino-1,2,4-triazoles by reductive ANRORC rearrangements of 1,2,4-oxadiazoles.
December 2010, The Journal of organic chemistry,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Antimicrobial activity of 5-substituted-3-amino-1,2,4-triazoles.
January 1994, Pharmacological research,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles.
May 2002, Organic letters,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
1,2,4-triazoles, III: new 1,5-diaryl-3-(substituted amino)-1H-1,2,4-triazoles as anti-inflammatory agents.
October 1989, Archiv der Pharmazie,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Chemotherapeutic agents, XV. Synthesis of 4-amino-3-pyrazolo-1,2,4-triazoles as antimicrobial agents.
February 1989, Archiv der Pharmazie,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives.
July 2022, Molecular diversity,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Efficient and regiospecific one-pot synthesis of substituted 1,2,4-triazoles.
August 2004, Organic letters,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
1,2,4-triazoles. VIII. Synthesis and antimicrobial activity of 3-alkylthio-5-pyridyl-1,2,4-triazoles and related compounds.
March 1978, Chemical & pharmaceutical bulletin,
Romain Noël, and Xinyi Song, and Rong Jiang, and Michael J Chalmers, and Patrick R Griffin, and Theodore M Kamenecka
Synthesis and pharmacological activities of some new 3-substituted-4-amino-5-mercapto-1,2,4-triazoles.
January 2011, Indian journal of pharmaceutical sciences,
Copied contents to your clipboard!