-transparent.png){kind=logo}
The development and sex differences of the catecholaminergic and serotoninergic systems were studied in rat caudate nucleus by measuring dopamine, serotonin and their metabolites in male and female pups from birth up to day 30 of life. Dopamine increased regularly during the entire period studied, while its metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), increased sharply only after day 9 of life. At birth, serotonin levels were 50% of the juvenile value; its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), increased greatly after day 6 of life. No difference was observed in male and female neurotransmitter ontogenesis. The results indicated that dopaminergic and serotoninergic systems were not mature in the caudate nucleus at birth. A functional immaturity of enzyme systems involved in neurotransmitter synthesis and/or catabolism is suggested.
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
January 1973,
Folia morphologica,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
January 1978,
Biulleten' eksperimental'noi biologii i meditsiny,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
June 1970,
Brain research,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
March 1975,
Arkhiv anatomii, gistologii i embriologii,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
January 1987,
Folia histochemica et cytobiologica,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
November 1997,
The Journal of pharmacology and experimental therapeutics,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
December 1974,
Science (New York, N.Y.),
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
January 1979,
Brain research,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
January 1980,
Journal of neural transmission,
P Restani, and
E Corsini, and
R Galimberti, and
C L Galli
September 1998,
Neuroscience letters,
