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Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-age Japanese men. 2009
Tomonori Okamura, and
Akira Sekikawa, and
Takashi Kadowaki, and
Aiman El-Saed, and
Robert D Abbott, and
J David Curb, and
Daniel Edmundowicz, and
Yasuyuki Nakamura, and
Kiyoshi Murata, and
Atsunori Kashiwagi, and
Kim Sutton-Tyrrell, and
Rhobert W Evans, and
Joseph M Zmuda, and
Hiroshi Maegawa, and
Atsushi Hozawa, and
Ken-Ichi Mitsunami, and
Yoshihiko Nishio, and
Iva Miljkovic-Gacic, and
Minoru Horie, and
Naomi Miyamatsu, and
Yoshitaka Murakami, and
Lewis H Kuller, and
Hirotsugu Ueshima
Preventive Cardiology, National Cardiovascular Center, Suita, Osaka, Japan. okamurat@hsp.ncvc.go.jp
The relation between cholesteryl ester transfer protein (CETP) levels and atherosclerosis is controversial. We examined whether the serum CETP levels were associated with subclinical atherosclerosis, independent of its most common gene variant, in a sample of Japanese men. A population-based cross-sectional study of 250 Japanese men aged 40 to 49 years was conducted to assess the intima-media thickness of the carotid artery, coronary artery calcium, serum CETP levels, and the CETP D442G gene variant. Compared with the lowest CETP quartile, the multivariate adjusted odds ratio for coronary artery calcium was 0.77 (95% confidence interval 0.18 to 3.36), 0.96 (95% confidence interval 0.27 to 3.40), and 3.49 (95% confidence interval 1.05 to 11.6) with increasing CETP quartiles. The serum CETP quartiles were also positively associated with the intima-media thickness of the carotid artery (adjusted mean 602, 616, 615, and 646 mum for the lowest to top quartile, respectively). The findings remained unchanged after additional adjustment for the CETP D442G gene variant. No significant difference was found in the prevalence of coronary artery calcium or in the mean intima-media thickness of the carotid artery between participants with and without the CETP D442G gene variant.
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