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Free radical production may cause myocardial damage during reperfusion of ischaemic myocardial tissue; when free radicals interact with polyunsaturated fatty acids or their esters, lipid peroxides are produced. A product of lipid peroxidation, malondialdehyde, was measured in 10 subjects with stable angina who underwent angioplasty of a proximal high-grade stenosis (over 90%) of the left anterior descending coronary artery. In all subjects the duration of balloon occlusion was 60 s. Blood was withdrawn from the great cardiac vein immediately before balloon inflation (T0), immediately after balloon deflation (T60), 15 s after balloon deflation (T75), and 1 min after balloon deflation (T120). There was a significant increase in malondialdehyde at T60 compared with T0 for the first balloon inflation (mean increase 0.3 mumol/l [95% confidence limits 0.1, 0.5]), and at both T60 (0.31 mumol/l [0.15, 0.47]) and T75 (0.22 mumol/l [0.04, 0.40]) for the second balloon inflation. This model could be used to assess antioxidant effects of drugs.
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
November 1990,
Journal of the American College of Cardiology,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
June 2001,
Japanese circulation journal,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
January 1995,
Vestnik rentgenologii i radiologii,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
July 1993,
British heart journal,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
April 1999,
International journal of cardiology,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
January 1991,
Annual review of medicine,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
June 2000,
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
April 1995,
Catheterization and cardiovascular diagnosis,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
January 1995,
Terapevticheskii arkhiv,
M J Roberts, and
I S Young, and
T G Trouton, and
E R Trimble, and
M M Khan, and
S W Webb, and
C M Wilson, and
G C Patterson, and
A A Adgey
December 1998,
The New England journal of medicine,
