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Islet cell tumors have been described the past 25 years in frequent series. Multiple symptoms lead often to prolongation of disease and misinterpretation of diagnosis. Because of its rarity most authors report only few cases. We had the chance to observe 24 patients of which four had carcinoma within 12 years. Symptoms, clinic, different surgical procedures are described. Clinical difference seems to exists between benigne and malignant islet cell tumors.
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