2',3'-Dideoxyinosine in patients with AIDS or AIDS-related complex. 1990

R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.

Twenty-one patients with AIDS or AIDS-related complex (ARC) received 2',3'-dideoxyinosine (didanosine; ddI) intravenously and then orally (initial dosages of 0.4 mg/kg and 0.8 mg/kg every 12 hours, respectively) for 6-44 weeks in an escalating-dose study. The major dose-limiting effects were peripheral neuropathy (three patients) and pancreatitis (two patients), which were observed at dosages greater than or equal to 20 mg/(kg.d). Hyperuricemia occurred at greater than or equal to 30 mg/(kg.d). No hematologic toxicity developed except for possible sporadic thrombocytopenia (two patients). Significant decreases in serum levels of p24 antigen and increases in CD4+ and CD8+ lymphocytes were noted at 2, 6, and 10-20 weeks and over a wide range of dosages, including the lowest given. Most patients had an increased feeling of well-being and/or a weight gain of greater than or equal to 2 kg at 6 weeks. For this population, ddI has promise as a therapeutic agent, thus warranting further study of this agent in controlled clinical trials.

UI MeSH Term Description Entries
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010195 Pancreatitis INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis. Acute Edematous Pancreatitis,Acute Pancreatitis,Pancreatic Parenchyma with Edema,Pancreatic Parenchymal Edema,Pancreatitis, Acute,Pancreatitis, Acute Edematous,Peripancreatic Fat Necrosis,Acute Edematous Pancreatitides,Acute Pancreatitides,Edema, Pancreatic Parenchymal,Edematous Pancreatitides, Acute,Edematous Pancreatitis, Acute,Fat Necrosis, Peripancreatic,Necrosis, Peripancreatic Fat,Pancreatic Parenchymal Edemas,Pancreatitides, Acute,Pancreatitides, Acute Edematous,Parenchymal Edema, Pancreatic,Peripancreatic Fat Necroses
D010523 Peripheral Nervous System Diseases Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves. Peripheral Nerve Diseases,Peripheral Neuropathies,PNS (Peripheral Nervous System) Diseases,PNS Diseases,Peripheral Nervous System Disease,Peripheral Nervous System Disorders,Nerve Disease, Peripheral,Nerve Diseases, Peripheral,Neuropathy, Peripheral,PNS Disease,Peripheral Nerve Disease,Peripheral Neuropathy
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000163 Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993. AIDS,Immunodeficiency Syndrome, Acquired,Immunologic Deficiency Syndrome, Acquired,Acquired Immune Deficiency Syndrome,Acquired Immuno-Deficiency Syndrome,Acquired Immuno Deficiency Syndrome,Acquired Immuno-Deficiency Syndromes,Acquired Immunodeficiency Syndromes,Immuno-Deficiency Syndrome, Acquired,Immuno-Deficiency Syndromes, Acquired,Immunodeficiency Syndromes, Acquired,Syndrome, Acquired Immuno-Deficiency,Syndrome, Acquired Immunodeficiency,Syndromes, Acquired Immuno-Deficiency,Syndromes, Acquired Immunodeficiency
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
October 1993, Clinical and diagnostic virology,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
September 1990, Lancet (London, England),
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
January 1990, Reviews of infectious diseases,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
May 1990, The New England journal of medicine,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
March 1992, Journal of clinical pharmacology,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
November 1991, The American journal of medicine,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
January 1993, The Journal of infectious diseases,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
May 1990, The New England journal of medicine,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
January 1991, Journal of clinical laboratory analysis,
R Dolin, and J S Lambert, and G D Morse, and R C Reichman, and C S Plank, and J Reid, and C Knupp, and C McLaren, and C Pettinelli
January 1990, Reviews of infectious diseases,
Copied contents to your clipboard!