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Propranolol antihemolytic test parameters calculated with the Hill mathematical model from dose-dependent curves of saturation were studied in 27 patients with myocardial infarction. Erythrocyte beta-adrenoreceptors showed higher sensitivity to propranolol in patients with myocardial infarction within 3 days of the disease. Three weeks after therapy, changes were found in the erythrocyte membranes solely in patients receiving beta-adrenoblockers. The changes are indicative of lower sensitivity of beta-adrenoreceptors to the beta-blocker. Persons with varying responses to propranolol were detected among the patients with myocardial infarction, which may be used to define indications for beta-adrenoblocker therapy.
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Iu V Anshelevich, and
K V Okun'
August 1977,
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Vrachebnoe delo,
