Association between cyclin D1 (CCND1) polymorphism and gastric cancer risk in Japanese population. 2009

Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
Department of Gastroenterology, Fujita Health University School of Medicine, Japan. tomomiccyu@yahoo.co.jp

OBJECTIVE A complex interaction of genetic and environmental factors is relevant in gastric carcinogenesis. Cyclin D1 (CCND1) is known to regulate function in G1 arrest and therefore, may play an important role in carcinogenesis. The present study aimed to clarify the effect of G870A polymorphism of the CCND1 gene on the risk of gastric cancer (GC) in a Japanese population. METHODS Restriction fragment length polymorphism analysis was performed for polymorphisms at 870GA in the CCND1 gene in 392 GC and 359 cancer-free subjects including 203 H. pylori positive gastritis and 156 H. pylori negative healthy stomach RESULTS Non significant association was found between CCND1 G870A genotypes and risk of GC when compared to that of all non-cancer subjects (AA vs. GG+GA: OR = 1.13, 95% CI = 0.81-1.58, A carrier vs. GG: OR = 1.13, 95% CI = 0.81-1.56), healthy stomach(AA vs. GG+GA: OR = 1.27, 95% CI = 0.81-2.00, A carrier vs. GG: OR = 1.13, 95% CI = 0.8-1.84) and gastritis. (AA vs. GG+GA: OR = 1.03, 95% CI = 0.7-1.53, p = 0.92, A carrier vs. GG: 1.06, 95% CI = 0.72-1.56, p = 0.77) No association was found between CCND1 genotypes and any of clinico-pathological features of GC. CONCLUSIONS It appears that the G870 polymorphism of CCND1 is not associated with the risk of GC in the Japanese population.

UI MeSH Term Description Entries
D007564 Japan A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo. Bonin Islands
D008297 Male Males
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013274 Stomach Neoplasms Tumors or cancer of the STOMACH. Cancer of Stomach,Gastric Cancer,Gastric Neoplasms,Stomach Cancer,Cancer of the Stomach,Gastric Cancer, Familial Diffuse,Neoplasms, Gastric,Neoplasms, Stomach,Cancer, Gastric,Cancer, Stomach,Cancers, Gastric,Cancers, Stomach,Gastric Cancers,Gastric Neoplasm,Neoplasm, Gastric,Neoplasm, Stomach,Stomach Cancers,Stomach Neoplasm
D016480 Helicobacter pylori A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405). Campylobacter pylori,Campylobacter pylori subsp. pylori,Campylobacter pyloridis,Helicobacter nemestrinae
D016481 Helicobacter Infections Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease. Infections, Helicobacter,Helicobacter Infection,Infection, Helicobacter

Related Publications

Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
October 2016, Oncotarget,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
March 2016, Medical science monitor : international medical journal of experimental and clinical research,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
May 2006, Cancer letters,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
December 2014, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
July 1999, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
October 2006, Cancer genetics and cytogenetics,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
December 2018, Bioscience reports,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
December 2013, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
January 2014, Asian Pacific journal of cancer prevention : APJCP,
Tomomitsu Tahara, and Tomiyasu Arisawa, and Tomoyuki Shibata, and Hiromi Yamashita, and Ichiro Hirata
August 2014, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
Copied contents to your clipboard!