BIOMAT Database Logo BIOMAT Database Logo

Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis. 1990

C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK.

The DNA of paired tumour and blood leucocyte samples from a large series of breast cancer patients was analysed to map regions of loss of heterozygosity on chromosome 17. The high frequency of loss of heterozygosity on 17p was confirmed, and a third of informative tumours had also lost an allele at the long arm locus THH59. On the short arm two distinct regions of loss of heterozygosity were identified, in bands p13-3 and p13-1. The latter probably involves the structural gene p53, which has been implicated as an oncogene or as a tumour suppressor in various human cancers. 17p 13-3, however, showed a significantly higher frequency of loss of heterozygosity, and there was no correlation between allele losses at the two sites. Nevertheless, loss of heterozygosity at 17p 13-3 is associated with overexpression of p53 mRNA, suggesting the existence of a gene some 20 megabases telomeric of p53 that regulates its expression. Lesions of this regulatory gene seem to be involved in the majority of breast cancers.

UI MeSH Term Description Entries
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D002872 Chromosome Deletion Actual loss of portion of a chromosome. Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D002886 Chromosomes, Human, Pair 17 A specific pair of GROUP E CHROMOSOMES of the human chromosome classification. Chromosome 17
D004273 DNA, Neoplasm DNA present in neoplastic tissue. Neoplasm DNA
D005260 Female Females
D006579 Heterozygote An individual having different alleles at one or more loci regarding a specific character. Carriers, Genetic,Genetic Carriers,Carrier, Genetic,Genetic Carrier,Heterozygotes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000483 Alleles Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product. Allelomorphs,Allele,Allelomorph

Related Publications

C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9.
June 1992, Nature genetics,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer.
February 1994, Genes, chromosomes & cancer,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
Allele loss patterns on chromosome 17q in 109 breast carcinomas indicate at least two distinct target regions.
March 1993, Oncogene,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
Evidence for at least eight Fanconi anemia genes.
October 1997, American journal of human genetics,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes.
March 1979, Proceedings of the National Academy of Sciences of the United States of America,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
Evidence for two schizophrenia susceptibility genes on chromosome 22q13.
October 2007, Psychiatric genetics,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
The telomere of human chromosome 1p contains at least two independent autosomal dominant congenital cataract genes.
July 2005, The British journal of ophthalmology,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption.
October 2006, Journal of lipid research,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
The ebg operon consists of at least two genes.
December 1980, Journal of bacteriology,
C Coles, and A M Thompson, and P A Elder, and B B Cohen, and I M Mackenzie, and G Cranston, and U Chetty, and J Mackay, and M Macdonald, and Y Nakamura
Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.
July 2015, eLife,
Copied contents to your clipboard!