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The isolation and localization of a chromosome 12-specific alpha satellite DNA sequence, p alpha 12H8, is described. This clone contains a complete copy of the 1.4-kb HindIII higher-order repeat present within the alpha satellite array on chromosome 12. The specificity of p alpha 12H8 was demonstrated by in situ hybridization and Southern blot analysis of a somatic cell hybrid mapping panel, both performed under high-stringency conditions. Polymorphic restriction patterns within the alpha satellite array, revealed by the use of the restriction enzymes BglII and EcoRV, were demonstrated to display Mendelian inheritance. These properties make p alpha 12H8 a valuable genetic marker for the centromeric region of chromosome 12.
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
March 1994,
Gene,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
April 1990,
American journal of human genetics,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
November 1993,
Genomics,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
March 1991,
Chromosoma,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
May 1990,
Genomics,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
May 1992,
Genomics,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
May 1985,
American journal of human genetics,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
August 1987,
DNA (Mary Ann Liebert, Inc.),
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
January 1988,
Doklady Akademii nauk SSSR,
L H Looijenga, and
V T Smit, and
J W Wessels, and
P Mollevanger, and
J W Oosterhuis, and
C J Cornelisse, and
P Devilee
December 1989,
American journal of human genetics,
