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American cutaneous leishmaniasis is a disease of skin and mucous membranes in which T lymphocytes reactive to Leishmania (Viannia) braziliensis are thought to contribute to protective immunity. To characterize the nature of the T cell inflammatory infiltrate in American cutaneous leishmaniasis lesions, immunohistochemistry with mAb that define T cell subpopulations and in situ hybridization to detect mRNA coding for IFN-gamma were performed. In both localized cutaneous (LCL) and mucocutaneous (MCL) lesions, we observed a predominance of T memory (CD4+CD45RO+) as compared to T naive cells (CD+CD45RA+). The percentages of cells containing IFN-gamma mRNA were equivalent in both LCL and MCL lesions. T cells were extracted from LCL and MCL lesions and analysis indicated that T cells from both lesions had been stimulated by L. (V.) braziliensis in vivo and gave equivalent proliferative responses in vitro. The present data suggest that T memory cells, which are likely to elaborate IFN-gamma, are components of DTH response to L. (V.) braziliensis and participate in the pathogenesis of both LCL and MCL lesions.
C Pirmez, and
C Cooper, and
M Paes-Oliveira, and
A Schubach, and
V K Torigian, and
R L Modlin
August 1965,
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C Pirmez, and
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M Paes-Oliveira, and
A Schubach, and
V K Torigian, and
R L Modlin
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C Pirmez, and
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R L Modlin
January 1998,
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C Pirmez, and
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R L Modlin
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C Pirmez, and
C Cooper, and
M Paes-Oliveira, and
A Schubach, and
V K Torigian, and
R L Modlin
December 2005,
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C Pirmez, and
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A Schubach, and
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R L Modlin
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C Pirmez, and
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M Paes-Oliveira, and
A Schubach, and
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R L Modlin
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C Pirmez, and
C Cooper, and
M Paes-Oliveira, and
A Schubach, and
V K Torigian, and
R L Modlin
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C Pirmez, and
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M Paes-Oliveira, and
A Schubach, and
V K Torigian, and
R L Modlin
January 1965,
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C Pirmez, and
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A Schubach, and
V K Torigian, and
R L Modlin
August 1958,
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