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Modeling schizophrenic-like neuronal patterns using nonlinear delayed differential equations. 2009

Sareh Zendehrouh, and Fatemeh Bakouie, and Shahriar Gharibzadeh
Faculty of Biomedical Engineering, Amirkabir University of Technology , Tehran 15875 4413, Iran.

We examined the simultaneous effect of altered dopamine and glutamate level on pyramidal cells using a mathematical model. The simulation results suggest that increased dopamine brings about irregular and aperiodic activity, interpreted as schizophrenic state. Hypoglutamatergic conditions have the same effect on the membrane potential of pyramidal cells. Increased glutamate level was able to neutralize the effects of the hyperdopamine state and normal periodic bursting behavior appeared. We suggest that glutamate receptor activation may have therapeutic results in schizophrenic patients. Surely, this hypothesis must be evaluated in the light of experimental studies on animal models or clinical trials.

UI MeSH Term Description Entries
D008962 Models, Theoretical Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Experimental Model,Experimental Models,Mathematical Model,Model, Experimental,Models (Theoretical),Models, Experimental,Models, Theoretic,Theoretical Study,Mathematical Models,Model (Theoretical),Model, Mathematical,Model, Theoretical,Models, Mathematical,Studies, Theoretical,Study, Theoretical,Theoretical Model,Theoretical Models,Theoretical Studies
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012559 Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder

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