BIOMAT Database Logo BIOMAT Database Logo

Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis. 2009

Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Department of Oral Diagnosis, University of São Paulo, SP, Brazil.

The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the patients were then instructed to discontinue the treatment for 2 weeks, and were then given container 2, used in the same way and for the same length of time as container 1. Regarding signs, 17 patients presented some improvement, while 5 experienced worsening with clobetasol propionate. With the placebo, 14 patients presented some improvement, and 8 patients presented worsening. For symptoms, there was complete improvement in 2 patients, partial improvement in 12, no response in 7, and worsening in 1 with clobetasol propionate. With the placebo, there was partial improvement in 8 patients, no response in 12 and worsening in 2. No statistically significant difference was found between clobetasol and placebo (p>0.05). Within the period designed to treat the gingival lesions of the patients, clobetasol propionate did not significantly outperform the placebo.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010392 Pemphigus Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS. Pemphigus Vulgaris,Pemphigus Foliaceus,Foliaceus, Pemphigus
D002990 Clobetasol A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression. Clobetasol 17-Propionate,Clobetasol Propionate,Clobex,Clofenazon,Cormax,Dermovate,Embeline,Embeline E,OLUX,Temovate,Clobetasol 17 Propionate
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D005891 Gingivitis Inflammation of gum tissue (GINGIVA) without loss of connective tissue. Gingivitides
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000287 Administration, Topical The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example. Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D000305 Adrenal Cortex Hormones HORMONES produced by the ADRENAL CORTEX, including both steroid and peptide hormones. The major hormones produced are HYDROCORTISONE and ALDOSTERONE. Adrenal Cortex Hormone,Corticoid,Corticoids,Corticosteroid,Corticosteroids,Cortex Hormone, Adrenal,Hormone, Adrenal Cortex,Hormones, Adrenal Cortex

Related Publications

Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Randomized, placebo-controlled, double-blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus.
July 2018, Oral diseases,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial.
January 2001, International journal of clinical pharmacology research,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0·1% vs. clobetasol propionate 0·05% in childhood vitiligo.
September 2011, The British journal of dermatology,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Efficacy and safety of a new clobetasol propionate 0.05% foam in alopecia areata: a randomized, double-blind placebo-controlled trial.
November 2006, Journal of the European Academy of Dermatology and Venereology : JEADV,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial.
January 1997, The American journal of medicine,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Ant venom immunotherapy: a double-blind, placebo-controlled, crossover trial.
March 2003, Lancet (London, England),
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Double-blind, crossover, placebo-controlled clinical trial with L-acetylcarnitine in patients with degenerative cerebellar ataxia.
January 2000, Clinical neuropharmacology,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
A double blind crossover placebo controlled trial of ximoprofen in as.
August 1989, The Journal of rheumatology,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Double-blind, crossover, placebo-controlled trial of bromocriptine in patients with sleep bruxism.
January 2001, Clinical neuropharmacology,
Ana Carolina Fragoso Motta, and Carina Domaneschi, and Marilena Chinali Komesu, and Cacilda da Silva Souza, and Valéria Aoki, and Dante Antonio Migliari
Tetracycline and epidermolysis bullosa simplex: a double-blind, placebo-controlled, crossover randomized clinical trial.
March 2004, The British journal of dermatology,
Copied contents to your clipboard!