BACKGROUND The aim of this study was to investigate weather beta blockers are associated with an increased mortality in sepsis. METHODS Data on 83 patients with sepsis treated in ICU were analyzed from the retrospective chart review. The association between treatment with Beta blockers and mortality was analyzed by logistic regression in univariate model and after adjusting for the APACHE morbidity/ mortality scores. RESULTS Among 83 patients (mean age 56.2+/-17.3 years, female 51%, the mean APACHE score 74.8+/-23.3), 29 were treated with BB. Those treated with BB had APACHE score of 79.93+/-23.47 and those not treated with BB had APACHE score of 73.67+/-23.21. No significant difference between the traditional cardiovascular risk factors was found in both groups except for HTN. Treatment with BB was not significantly associated with mortality in the univariate (OR=1.83, 95% CI 0.59-5.69) nor multivariate model (OR=1.843, 95% CI 0.56-6.10). The APACHE score was a strong predictor of mortality (OR=1.04, 95% CI 1.01-1.06, p=0.02). This association was independent of BB use, and no significant interaction (p=0.72) between BB and APACHE score was observed. CONCLUSIONS We did not show a significant association between beta blockers and increased mortality in patients with sepsis. Sicker patients had an increase risk of death, and possibility that beta blocker use may have contributed to this risk cannot be completely ruled out. Our study was limited by a small sample size and retrospective design. Further investigations of potential benefits and side effect of beta blockers in patients with sepsis are warranted.