Biomaterial Database

Sexual side effects of antipsychotic medication: evaluation and interventions. 1990

G Sullivan, and D Lukoff

Rehabilitation Service, Brentwood Veterans Affairs, West Los Angeles, California.

Sexual side effects of antipsychotic medications, which include disturbances of erection and ejaculation, changes in libido, and priapism in men and decreased libido, orgasmic dysfunction, and menstrual irregularities in women, are estimated to occur in 30 to 60 percent of persons taking the drugs. The authors review side effects associated with specific drugs and present guidelines for assessing whether sexual dysfunction is related to medication. Pharmacological interventions that may reduce antipsychotic-induced sexual dysfunction include gradually reducing the dose or changing the type of medication and administering other medications such as bethanechol, neostigmine, cyproheptadine, and bromocriptine that are known to improve sexual dysfunction.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D014150	Antipsychotic Agents	Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.	Antipsychotic,Antipsychotic Agent,Antipsychotic Drug,Antipsychotic Medication,Major Tranquilizer,Neuroleptic,Neuroleptic Agent,Neuroleptic Drug,Neuroleptics,Tranquilizing Agents, Major,Antipsychotic Drugs,Antipsychotic Effect,Antipsychotic Effects,Antipsychotics,Major Tranquilizers,Neuroleptic Agents,Neuroleptic Drugs,Tranquillizing Agents, Major,Agent, Antipsychotic,Agent, Neuroleptic,Drug, Antipsychotic,Drug, Neuroleptic,Effect, Antipsychotic,Major Tranquilizing Agents,Major Tranquillizing Agents,Medication, Antipsychotic,Tranquilizer, Major
D020018	Sexual Dysfunctions, Psychological	Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)	Frigidity,Hypoactive Sexual Desire Disorder,Orgasmic Disorder,Psychosexual Disorders,Psychosexual Dysfunctions,Sexual Arousal Disorder,Sexual Aversion Disorder,Arousal Disorders, Sexual,Aversion Disorders, Sexual,Disorder, Psychosexual,Disorders, Orgasmic,Disorders, Psychosexual,Disorders, Sexual Arousal,Disorders, Sexual Aversion,Dysfunction, Psychological Sexual,Dysfunction, Psychosexual,Dysfunctions, Psychological Sexual,Dysfunctions, Psychosexual,Orgasmic Disorders,Psychological Sexual Dysfunction,Psychological Sexual Dysfunctions,Psychosexual Disorder,Psychosexual Dysfunction,Sexual Arousal Disorders,Sexual Aversion Disorders,Sexual Dysfunction, Psychological