-transparent.png){kind=logo}
Stereoselective effect of warfarin and bilirubin on the binding of 5-(o-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H-1,4-benzodiazepin-2- one enantiomers to human serum albumin. 1990
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
The binding of the title benzodiazepine enantiomers and its modulation by warfarin and bilirubin were studied by chromatography on human serum albumin (HSA) immobilized on Sepharose 4B, and also by a combination of ultrafiltration and circular dichroism (UF-CD) methods. In the absence of warfarin and bilirubin the binding of the benzodiazepine was not stereoselective. (S)-Benzodiazepine and (S)-warfarin mutually increased the binding of each other, while the binding of (R)-benzodiazepine was preferentially enhanced on HSA saturated with bilirubin.
Related Publications
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
March 1977,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
July 1971,
Arzneimittel-Forschung,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
February 1977,
Arzneimittel-Forschung,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
March 1972,
Arzneimittel-Forschung,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
January 1977,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
July 1971,
Arzneimittel-Forschung,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
December 1978,
Journal of pharmaceutical sciences,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
April 1965,
Arzneimittel-Forschung,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
August 1979,
Xenobiotica; the fate of foreign compounds in biological systems,
I Fitos, and
J Visy, and
A Magyar, and
J Kajtár, and
M Simonyi
December 1974,
Die Pharmazie,
