Infectious diseases in pediatric transplantation: review of the literature 2007-2008. 2010

Arnaud G L'huillier, and Klara M Posfay-Barbe
Department of Pediatrics, Children's Hospital of Geneva, University Hospitals of Geneva, Switzerland.

After the first decades in the history of (pediatric) transplantation which focused on finding proper surgical techniques and the best immunosuppressive regimen, infections have been increasingly recognized as important for survival and quality of life in transplant recipients, and many researchers work on either decreasing the risk for infection or treating it (or both). This not exhaustive review of the scientific articles published between 2007 and 2008 looks from the infectious diseases point of view at the most exciting information for different types of transplanted organs. It reviews new approaches to frequent infections, such as BK virus, cytomegalovirus, Epstein-Barr virus, and adenoviral infections but also to Aspergillus and mold infections, which are linked with high mortality rates in transplant recipients. It also examines novel markers to discriminate between infection and rejection. Comments to each manuscript have been added, but we strongly encourage the reader to refer to the original work for more in depth evaluation.

UI MeSH Term Description Entries
D007239 Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. Infection,Infection and Infestation,Infections and Infestations,Infestation and Infection,Infestations and Infections
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D014943 Global Health A multi- and interdisciplinary field concerned with improving health and achieving equity in health for all people. It transcends national boundaries, promotes cooperation and collaboration within and beyond health science fields, and combines population-based disease prevention with individually-based patient care. International Health Problems,World Health,International Health,Worldwide Health,Health Problem, International,Health Problems, International,Health, Global,Health, International,Health, World,Health, Worldwide,Healths, International,International Health Problem,International Healths,Problem, International Health,Problems, International Health
D016377 Organ Transplantation Transference of an organ between individuals of the same species or between individuals of different species. Grafting, Organ,Transplantation, Organ,Graftings, Organ,Organ Grafting,Organ Graftings,Organ Transplantations,Transplantations, Organ
D017053 Infection Control Programs of disease surveillance, generally within health care facilities, designed to investigate, prevent, and control the spread of infections and their causative microorganisms. Control, Infection

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