Biomaterial Database

[Updates on ossification of posterior longitudinal ligament. Bone metabolism in ossification of posterior longitudinal ligament]. 2009

Hironari Takaishi, and Yuta Shiono, and Morio Matsumoto

Department of Orthopaedic Surgery, Keio Univerrsity, School of Medicine.

Ossification of the longitudinal ligament in the spine is a disorder of unknown cause characterized by ectopic ossification. In the animal models of spinal hyperostosis, the vertebral ligament is gradually replaced by bony tissue forming an osseous bridge around enthesis, and a high turnover osteopenia occurs after the maturation in the trabecular bone of vertebrae. It has been suggested that the recruited vasculature facilitated the filling of the niche with host-derived haematopoietic cells during the ectopic ossification process. Recent data suggest that regulation of hematopoietic and osteogenic stem/progenitor cell populations may contribute to the formation of an ectopic spinal hyperostosis.

UI	MeSH Term	Description	Entries
D009999	Ossification, Heterotopic	The development of bony substance in normally soft structures.	Ossification, Pathologic,Ectopic Ossification,Heterotopic Ossification,Ossification, Ectopic,Ossification, Pathological,Pathologic Ossification,Pathological Ossification
D001851	Bone Diseases, Metabolic	Diseases that affect the METABOLIC PROCESSES of BONE TISSUE.	Low Bone Density,Low Bone Mineral Density,Osteopenia,Metabolic Bone Diseases,Bone Density, Low,Bone Disease, Metabolic,Low Bone Densities,Metabolic Bone Disease,Osteopenias
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006412	Hematopoietic Stem Cells	Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood.	Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013131	Spine	The spinal or vertebral column.	Spinal Column,Vertebrae,Vertebral Column,Vertebra,Column, Spinal,Column, Vertebral,Columns, Spinal,Columns, Vertebral,Spinal Columns,Vertebral Columns
D015576	Hyperostosis	Increase in the mass of bone per unit volume.	Bone Hypertrophy,Bone Hypertrophies,Hyperostoses,Hypertrophies, Bone,Hypertrophy, Bone
D017887	Ossification of Posterior Longitudinal Ligament	A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. It is often associated with anterior ankylosing hyperostosis.	Calcification of Posterior Longitudinal Ligament,Posterior Longitudinal Ligament Calcification,Posterior Longitudinal Ligament Ossification